阿尔茨海默病中的视网膜厚度：一项系统评价和荟萃分析。
Retinal thickness in Alzheimer's disease: A systematic review and meta-analysis.
作者信息
den Haan Jurre, Verbraak Frank D, Visser Pieter Jelle, Bouwman Femke H
机构信息
Neurology, VU University Medical Center Alzheimer Center, Amsterdam, The Netherlands.
Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Ophthalmology Department, VU University Medical Center, Amsterdam, The Netherlands.
出版信息
Alzheimers Dement (Amst). 2017 Jan 25;6:162-170. doi: 10.1016/j.dadm.2016.12.014. eCollection 2017.
INTRODUCTION
Retinal characteristics are increasingly recognized as biomarkers for neurodegenerative diseases. Retinal thickness measured by optical coherence tomography may reflect the presence of Alzheimer's disease (AD). We performed a meta-analysis on retinal thickness in AD and mild cognitive impairment (MCI) patients and healthy controls (HCs).
METHODS
We selected 25 studies with measurements of retinal thickness including 887 AD patients, 216 MCI patients, and 864 HCs that measured retinal thickness. Outcomes were peripapillary retinal nerve fiber layer (RNFL) and macular thickness. The main outcome was the standardized mean differences (SMDs). We used STATA to perform the meta-analysis (StataCorp, Texas; version 14.0).
RESULTS
Relative to HCs, AD and MCI patients had lower peripapillary RNFL (SMD 0.98 [CI -1.30, -0.66, < .0001] and SMD 0.71 [CI -1.24, -0.19, = .008]). Total macular thickness was decreased in AD patients (SMD 0.88 [CI -1.12, -0.65, = .000]).
DISCUSSION
Retinal thickness is decreased in AD and MCI patients compared to HC. This confirms that neurodegenerative diseases may be reflected by retinal changes.
引言
视网膜特征越来越被认为是神经退行性疾病的生物标志物。通过光学相干断层扫描测量的视网膜厚度可能反映阿尔茨海默病（AD）的存在。我们对AD患者、轻度认知障碍（MCI）患者和健康对照者（HCs）的视网膜厚度进行了荟萃分析。
方法
我们选择了25项测量视网膜厚度的研究，其中包括887例AD患者、216例MCI患者和864例测量视网膜厚度的HCs。观察指标为视乳头周围视网膜神经纤维层（RNFL）和黄斑厚度。主要观察指标为标准化平均差（SMD）。我们使用STATA进行荟萃分析（StataCorp，德克萨斯州；版本14.0）。
结果
相对于HCs，AD患者和MCI患者的视乳头周围RNFL较低（SMD为0.98 [CI -1.30，-0.66，<0.0001]和SMD为0.71 [CI -1.24，-0.19，=0.008]）。AD患者的黄斑总厚度降低（SMD为0.88 [CI -1.12，-0.65，=0.000]）。
讨论
与HCs相比，AD患者和MCI患者的视网膜厚度降低。这证实了神经退行性疾病可能由视网膜变化反映出来。
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