Song Jie, Zhang Lingli, Li Youping, Zeng Linan, Hu Die, Liang Yi, Liu Dan
Department of Pharmacy, West China Second University Hospital, Sichuan University, Chengdu, China.
Evidence-Based Pharmacy Center, West China Second University Hospital, Sichuan University, Chengdu, China.
J Evid Based Med. 2017 Aug;10(3):222-232. doi: 10.1111/jebm.12244. Epub 2017 May 24.
We searched and described existing drug-related indicators, and provided helps for using indicators for quality assessment of drug use and developing new indicators.
We searched 8 databases and 41 official WebPages of national pharmaceutical administration department or academic organizations to obtain literature on drug-related indicators. Researchers extracted data including basic information (countries, issue time et al.), target population, categories, and various characters of indicators. We finally conducted a descriptive analysis to summarize these indicators.
A total of 3598 literatures were retrieved, 39 of which were finally included. a) A total of 876 indicators were identified. Of which, 9.5% were structure indicator, 83.6% were process indicator and 6.9% were outcome indicator. b) Evaluation dimensions of indicators could be summarized as prescribing quality, patients' experience, pharmacy administration, drug-therapy process and cost. c) In included indicator sets, 9 were developed for specific drug, 7 were for specific disease and 6 were for specific population. d) Instructions of indicator sets were identified. 7 terms of instructions were included such as rationale, prerequisite and definition of indicators.
Most study suggest that prescribing quality is an essential dimension and process indicator was greatly considered in drug use evaluation. Drug-related indicators for general adults were relatively well-developed. There was an urgent need for investigation of drug use indicators for children and pregnant women.
检索并描述现有的药物相关指标，为将指标用于药物使用质量评估及开发新指标提供帮助。
检索8个数据库以及国家药品管理部门或学术组织的41个官方网页，以获取有关药物相关指标的文献。研究人员提取的数据包括基本信息（国家、发布时间等）、目标人群、类别以及指标的各种特征。最后进行描述性分析以总结这些指标。
共检索到3598篇文献，最终纳入39篇。a）共识别出876个指标。其中，结构指标占9.5%，过程指标占83.6%，结果指标占6.9%。b）指标的评价维度可归纳为处方质量、患者体验、药房管理、药物治疗过程和成本。c）在纳入的指标集中，9个是针对特定药物制定的，7个是针对特定疾病的，6个是针对特定人群的。d）识别出指标集的说明。包括指标的基本原理、前提条件和定义等7项说明。
大多数研究表明，处方质量是一个重要维度，且在药物使用评估中对过程指标的考虑较多。针对一般成年人的药物相关指标相对完善。迫切需要对儿童和孕妇的药物使用指标进行研究。
