Hu Chu-Hong, Zhou Yan-Hui, Xie Fei, Li Yue-Lan, Zhao Zun-Tian, Lou Hong-Xiang
a Department of Natural Products Chemistry, Key Lab of Chemical Biology of Ministry of Education , Shandong University , Jinan 250012 , China.
J Asian Nat Prod Res. 2017 Aug;19(8):786-792. doi: 10.1080/10286020.2017.1283311. Epub 2017 Feb 28.
Two new α-pyrone derivatives, tolypocladones A (1) and B (2), together with five known compounds were isolated from an endolichenic fungus Tolypocladium sp. (4259a). The structures of all the compounds were determined by analysis of their MS and NMR data. Among them, compound 1 was an enantiomeric mixture and the configuration was established by single-crystal X-ray diffraction analysis using Cu-Kα radiation. Also, this is the first report of the presence of compound 3 (glycine, N-(2,3-dihydroxybenzoyl)-methyl ester) and compound 4 (2H-pyran-2-one, 4-methoxy-6-(1,3-pentadienyl)) as natural products.
从一种内生地衣真菌托孢壳属（Tolypocladium sp.）（4259a）中分离出两种新的α-吡喃酮衍生物，即托孢壳菌素A（1）和B（2），以及五种已知化合物。所有化合物的结构通过对其质谱和核磁共振数据的分析得以确定。其中，化合物1是对映体混合物，其构型通过使用Cu-Kα辐射的单晶X射线衍射分析确定。此外，这是首次报道化合物3（甘氨酸，N-（2,3-二羟基苯甲酰基）-甲酯）和化合物4（2H-吡喃-2-酮，4-甲氧基-6-（1,3-戊二烯基））作为天然产物存在。
