Yoshida T, Shimizu K, Ushio Y, Hayakawa T, Mogami H, Sakamoto Y, Egawa T
Department of Neurosurgery, Osaka University Medical School, Japan.
No To Shinkei. 1987 Aug;39(8):719-23.
Rat C 6 glioma is known to possess a beta-adrenergic receptor with which intracellular cyclic adenosine monophosphate (cAMP) levels are altered to control cell growth in vitro. In order to study the effect of beta-adrenergic agonist, isoproterenol, in growth-inhibitory action upon C 6 glioma cells, subcutaneous tumor models and meningeal gliomatisis (MG) models as a brain tumor model have been exposed to the treatment of isoproterenol. Growth of subcutaneous tumor was suppressed by the treatment of the drug, and the survival time of MG rats was prolonged by the intrathecal (i. t.) injection of isoproterenol. The addition of papaverine, phosphodiesterase inhibitor, to the treatment schedule augmented the growth-inhibitory effect of isoproterenol. Therefore, it is concluded that the survival time of the brain tumor models could be prolonged through the inhibition of the growth of C 6 glioma cells by such drugs as those which elevate intracellular cAMP levels.
已知大鼠C6胶质瘤细胞具有β-肾上腺素能受体，通过该受体可改变细胞内环状单磷酸腺苷（cAMP）水平，从而在体外控制细胞生长。为了研究β-肾上腺素能激动剂异丙肾上腺素对C6胶质瘤细胞生长抑制作用的影响，皮下肿瘤模型和作为脑肿瘤模型的脑膜胶质瘤病（MG）模型已接受异丙肾上腺素治疗。药物治疗可抑制皮下肿瘤的生长，鞘内注射异丙肾上腺素可延长MG大鼠的存活时间。在治疗方案中添加磷酸二酯酶抑制剂罂粟碱可增强异丙肾上腺素的生长抑制作用。因此，可以得出结论，通过使用能提高细胞内cAMP水平的药物抑制C6胶质瘤细胞的生长，可延长脑肿瘤模型的存活时间。
