Fedewa Michael V, Hathaway Elizabeth D, Higgins Simon, Das Bhibha M, Forehand Ronald L, Schmidt Michael D, Evans Ellen M
a Department of Kinesiology , The University of Alabama , Tuscaloosa , Alabama , USA.
b Department of Kinesiology , The University of Georgia , Athens , Georgia , USA.
Women Health. 2018 Feb;58(2):129-144. doi: 10.1080/03630242.2017.1292341. Epub 2017 Mar 6.
Oral contraceptives (OCs) are the most frequently used type of birth control among young women. OC-users have higher C-reactive protein (CRP) values, an indicator of systemic inflammation, than do non-OC-users. In addition, adiposity (percent fat) is positively associated with CRP, and physical activity (PA) is inversely associated with CRP. The present study determined the interactive associations of PA, percent fat, and OC-use with CRP. Data were collected during 2012-2015 at the University of Georgia. Objective PA was measured via pedometers. Percent fat was measured via dual X-ray absorptiometry. The current OC-use was self-reported. High-sensitivity (hs) CRP was determined using venipuncture. Multivariate linear regression determined the interactive associations of percent fat, OC-use, and PA with hs-CRP. Participants (n = 247; mean age 18.9 ± 1.4 years, 60.7 percent white) accumulated a mean of 10,075.7 ± 3,593.4 steps/day. One-third of participants were categorized as overweight/obese by BMI (mean = 24.5 ± 4.8 kg/m, mean percent fat = 35.2 ± 6.8). The current OC-use was reported by 26.2 percent of the sample (n = 61). A significant three-way interaction (β = 0.01, p = .03) indicated that higher PA was associated with lower hs-CRP in non-OC-users with higher percent fat, but not among OC-users with higher percent fat. These results highlight the need to measure and account for the current OC-use in studies examining the relationship between PA and CRP.
口服避孕药（OCs）是年轻女性中最常用的避孕方式。与未使用口服避孕药的女性相比，使用口服避孕药的女性体内C反应蛋白（CRP）值更高，而CRP是全身炎症的一个指标。此外，肥胖（脂肪百分比）与CRP呈正相关，而身体活动（PA）与CRP呈负相关。本研究确定了身体活动、脂肪百分比和口服避孕药使用与CRP之间的交互关联。数据于2012年至2015年在佐治亚大学收集。通过计步器测量客观身体活动量。通过双能X线吸收法测量脂肪百分比。当前口服避孕药的使用情况通过自我报告获得。采用静脉穿刺测定高敏（hs）CRP。多变量线性回归确定了脂肪百分比、口服避孕药使用和身体活动与hs-CRP之间的交互关联。参与者（n = 247；平均年龄18.9 ± 1.4岁，60.7%为白人）平均每天累积步数为10,075.7 ± 3,593.4步。三分之一的参与者根据体重指数被归类为超重/肥胖（平均 = 24.5 ± 4.8 kg/m，平均脂肪百分比 = 35.2 ± 6.8）。26.2%的样本（n = 61）报告了当前口服避孕药的使用情况。一个显著的三向交互作用（β = 0.01, p = 0.03）表明，在脂肪百分比更高的未使用口服避孕药的女性中，较高的身体活动与较低的hs-CRP相关，但在脂肪百分比更高的使用口服避孕药的女性中并非如此。这些结果凸显了在研究身体活动与CRP之间的关系时，测量并考虑当前口服避孕药使用情况的必要性。
