Pryor Jason, Patrick Stephen W, Sundermann Alexandra C, Wu Pingsheng, Hartmann Katherine E
Department of Pediatrics, the Mildred Stahlman Division of Neonatology, the Vanderbilt Center for Health Services Research, the Department of Health Policy, the Vanderbilt Center for Addiction Research, the Institute for Medicine and Public Health, the Department of Biostatistics, and the Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee.
Obstet Gynecol. 2017 Apr;129(4):727-733. doi: 10.1097/AOG.0000000000001933.
To evaluate whether women planning a pregnancy are less likely to use alcohol in early pregnancy than those with unintended pregnancies.
Right From the Start (2000-2012) is a prospective, community-based pregnancy cohort. Maternal demographic, reproductive, and behavioral data were collected in telephone interviews at enrollment (mean±standard deviation 48±13 days of gestation) and later in the first trimester (mean±standard deviation 85±21 days of gestation). Alcohol consumption characteristics were included in the interviews. We used logistic regression to investigate the association of pregnancy intention with alcohol use.
Among 5,036 women, 55% reported using alcohol in the first trimester with 6% continuing use at the first-trimester interview. Pregnancy was planned by 70% of participants. Alcohol use occurred in 55% and 56% of intended and unintended pregnancies, respectively (P=.32). Adjusting for confounders, women with intended pregnancies were 31% less likely to consume any alcohol in early pregnancy (adjusted odds ratio [OR] 0.69, 95% confidence interval [CI] 0.60-0.81) or binge drink (adjusted OR 0.68, 95% CI 0.54-0.86). Most women, regardless of intention, stopped or decreased alcohol consumption in early pregnancy.
The majority of women, irrespective of intention, stopped or decreased drinking after pregnancy recognition. This suggests promoting early pregnancy awareness could prove more effective than promoting abstinence from alcohol among all who could conceive.
评估计划怀孕的女性在孕早期饮酒的可能性是否低于意外怀孕的女性。
“从一开始”（2000 - 2012年）是一项基于社区的前瞻性妊娠队列研究。在入组时（妊娠平均±标准差48±13天）以及孕早期后期（妊娠平均±标准差85±21天）通过电话访谈收集产妇的人口统计学、生殖和行为数据。访谈中包括饮酒特征。我们使用逻辑回归来研究妊娠意愿与饮酒之间的关联。
在5036名女性中，55%报告在孕早期饮酒，其中6%在孕早期访谈时仍在饮酒。70%的参与者计划怀孕。计划妊娠和意外妊娠的女性中分别有55%和56%饮酒（P = 0.32）。在对混杂因素进行调整后，计划怀孕的女性在孕早期饮酒（调整后的优势比[OR] 0.69，95%置信区间[CI] 0.60 - 0.81）或暴饮（调整后的OR 0.68，95% CI 0.54 - 0.86）的可能性降低31%。大多数女性，无论妊娠意愿如何，在孕早期都停止或减少了饮酒。
大多数女性，无论妊娠意愿如何，在确认怀孕后都停止或减少了饮酒。这表明提高对早期妊娠的认知可能比在所有可能怀孕的人群中推广戒酒更有效。
