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怀孕意愿作为孕期暴露因素的预测指标:二者有关联吗?

Intent to become pregnant as a predictor of exposures during pregnancy: is there a relation?

作者信息

Than Lara C, Honein Margaret A, Watkins Margaret L, Yoon Paula W, Daniel Katherine Lyon, Correa Adolfo

机构信息

National Center on Birth Defects and Developmental Disabilities, and Office of Genomics and Disease Prevention, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA.

出版信息

J Reprod Med. 2005 Jun;50(6):389-96.

PMID:16050563
Abstract

OBJECTIVE

To evaluate the relationship between intent to be pregnant and selected maternal exposures during pregnancy.

STUDY DESIGN

In 1982-1983, 3,029 women who gave birth to infants without birth defects from 1968-1980 (the control mothers from a large case-control study of birth defects) completed a detailed telephone interview. This analysis examined behaviors reported in the third month of pregnancy because most women would be aware of their pregnancies by the end of the first trimester, and our primary interest was assessing exposures that occurred after pregnancy recognition.

RESULTS

Women who reported unintended pregnancies tended to be younger, nonwhite and less educated, and tended to have higher gravidity than women who reported intended pregnancies. After adjustingfor maternal age, education, race and previous adverse pregnancy outcome, women who reported unintended pregnancies were more likely to report smoking (odds ratio [OR] = 1.4, 95% confidence interval [CI] 1.2, 1.7), illicit drug use (OR=3.4, 95% CI 1.9, 6.4), not taking vitamins (OR = 1.4, 95% CI 1.2, 1.7), and alcohol use (OR=1.2, 95% CI 0.99, 1.4) than women who had intended pregnancies. No association was observed between pregnancy intention and medication use.

CONCLUSION

These results suggest that women who report having unintended pregnancies are more likely to have some exposures that may result in adverse pregnancy outcomes.

摘要

目的

评估怀孕意愿与孕期特定母亲暴露因素之间的关系。

研究设计

1982 - 1983年,3029名在1968 - 1980年生育无出生缺陷婴儿的女性(一项大型出生缺陷病例对照研究中的对照母亲)完成了详细的电话访谈。本分析考察了孕期第三个月报告的行为,因为大多数女性在孕早期结束时会意识到自己怀孕,而我们主要关注的是评估怀孕确认后发生的暴露情况。

结果

报告意外怀孕的女性往往更年轻、非白人且受教育程度较低,并且与报告有意怀孕的女性相比,她们的妊娠次数往往更高。在调整了母亲年龄、教育程度、种族和既往不良妊娠结局后,报告意外怀孕的女性比有意怀孕的女性更有可能报告吸烟(比值比[OR]=1.4,95%置信区间[CI]1.2,1.7)、使用非法药物(OR = 3.4,95% CI 1.9,6.4)、不服用维生素(OR = 1.4,95% CI 1.2,1.7)以及饮酒(OR = 1.2,95% CI 0.99,1.4)。未观察到怀孕意愿与用药之间的关联。

结论

这些结果表明,报告意外怀孕的女性更有可能有一些可能导致不良妊娠结局的暴露情况。

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