急性卒中的扩散加权和灌注加权磁共振成像：临床应用及治疗选择的潜在局限性
Diffusion and Perfusion MR Imaging in Acute Stroke: Clinical Utility and Potential Limitations for Treatment Selection.
作者信息
Bateman Mathew, Slater Lee-Anne, Leslie-Mazwi Thabele, Simonsen Claus Z, Stuckey Stephen, Chandra Ronil V
机构信息
*Neuroradiology Service, Monash Imaging, Monash Health †School of Clinical Sciences, Faculty of Medicine, Nursing and Health Sciences, Monash University, Melbourne, Victoria, Australia ‡NeuroEndovascular Service, Massachusetts General Hospital, Harvard Medical School, Boston, MA §Department of Neurology, Aarhus University Hospital, Aarhus, Denmark.
出版信息
Top Magn Reson Imaging. 2017 Apr;26(2):77-82. doi: 10.1097/RMR.0000000000000124.
Magnetic resonance (MR) diffusion-weighted imaging (DWI) and perfusion-weighted imaging (PWI) offer unique insight into acute ischemic stroke pathophysiology. These techniques may offer the ability to apply pathophysiology to accurately individualize acute stroke reperfusion treatment, including extending the opportunity of reperfusion treatment to well beyond the current time-based treatment windows.This review examines the use of DWI and PWI in the major stroke trials, their current clinical utility, and potential limitations for reperfusion treatment selection. DWI and PWI continue to be investigated in ongoing randomized controlled trials, and continued research into these techniques will help achieve the goal of tissue-based decision making and individualized acute stroke treatment.
磁共振（MR）扩散加权成像（DWI）和灌注加权成像（PWI）为急性缺血性脑卒中的病理生理学提供了独特的见解。这些技术可能提供将病理生理学应用于准确个体化急性卒中再灌注治疗的能力，包括将再灌注治疗的机会扩展到远远超出当前基于时间的治疗窗口。本综述探讨了DWI和PWI在主要卒中试验中的应用、它们目前的临床效用以及再灌注治疗选择的潜在局限性。DWI和PWI仍在正在进行的随机对照试验中进行研究，对这些技术的持续研究将有助于实现基于组织的决策和个体化急性卒中治疗的目标。
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