微小RNA对胚胎干细胞自我更新和分化的调控
Regulation of Embryonic Stem Cell Self-Renewal and Differentiation by MicroRNAs.
作者信息
Ran Xi, Xiao Chun-Hong, Xiang Gui-Ming, Ran Xin-Ze
机构信息
1 Department of Medical Laboratory, Xinqiao Hospital, Third Military Medical University , Chongqing, China .
2 State Key Laboratory of Trauma, Burns and Combined Injury, Institute of Combined Injury of PLA, College of Preventive Medicine, Third Military Medical University , Chongqing, China .
出版信息
Cell Reprogram. 2017 Jun;19(3):150-158. doi: 10.1089/cell.2016.0048. Epub 2017 Mar 9.
MicroRNAs (miRNAs) are posttranscriptional regulators of gene expression. They play an important role in various cellular processes such as apoptosis, differentiation, secretion, and proliferation. Embryonic stem cells (ESCs) are derived from the inner cell mass of the blastocyst stage of the embryo. miRNAs are critical factors for the self-renewal and differentiation of ESCs. In this review, we will focus on the role of miRNAs in the self-renewal and directional differentiation of ESCs. We will present the current knowledge on key points related to miRNA biogenesis and their function in ESCs.
微小RNA（miRNA）是基因表达的转录后调节因子。它们在各种细胞过程中发挥重要作用，如细胞凋亡、分化、分泌和增殖。胚胎干细胞（ESC）来源于胚胎囊胚期的内细胞团。miRNA是ESC自我更新和分化的关键因素。在本综述中，我们将重点关注miRNA在ESC自我更新和定向分化中的作用。我们将介绍有关miRNA生物发生及其在ESC中的功能相关要点的当前知识。
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