Imlah N W
Acta Psychiatr Scand Suppl. 1978(274):94-8. doi: 10.1111/j.1600-0447.1978.tb02392.x.
The presentation of anxiety in clinical practice is examined, and it is concluded that many patients, perhaps a majority, experience fluctuating levels of anxiety. It is therefore suggested that therapy should be intermittent, according to this waxing and waning of symptoms. Most benzodiazepines are long-acting, and are therefore unsuitable for this type of therapy, but oxazepam, which is short-acting and has no active metabolites, is ideal for this purpose. It is proposed that such a regimen would minimize the problems of over-sedation, psychological habituation, and a reluctance, due to a permanently tranquillized state, to deal with the root causes of the anxiety.
本文探讨了焦虑症在临床实践中的表现，并得出结论：许多患者，可能是大多数患者，经历着焦虑水平的波动。因此建议，根据症状的起伏，治疗应该是间歇性的。大多数苯二氮䓬类药物作用时间长，因此不适合这种治疗方式，但奥沙西泮作用时间短且无活性代谢产物，是这种治疗的理想选择。有人提出，这样的治疗方案将最大限度地减少过度镇静、心理成瘾以及由于长期处于镇静状态而不愿处理焦虑根源等问题。
