Silva E P, Borges L S, Mendes-da-Silva C, Hirabara S M, Lambertucci R H
a Institute of Physical Exercise Sciences and Sports, Cruzeiro do Sul University , Sao Paulo , Brazil.
b Laboratory of Neuroscience and Nutrition, Department of Biosciences , Federal University of Sao Paulo , Santos , Brazil.
Free Radic Res. 2017 Mar;51(3):281-293. doi: 10.1080/10715762.2017.1301664. Epub 2017 Mar 22.
Reactive species have great importance in sports performance, once they can directly regulate energy production, muscular contraction, inflammation, and fatigue. Therefore, the redox control is essential for athletes' performance. Studies demonstrated that l-arginine has an important role in the synthesis of urea, cell growth and production of nitric oxide, moreover, there are indications that it is also able to induce benefits to muscle antioxidant system through the upregulation of some antioxidant enzymes, and by inhibiting some pathways of reactive species production. Therefore, the aim of this study was to evaluate the effects of l-arginine supplementation on performance and oxidative stress of male rats (trained or not), submitted to a single session of high intensity exercise. Forty male Wistar rats were divided into four groups, control (C), control+l-arginine (C + A), trained (T), and trained+l-arginine (T + A). The aerobic training was conducted for 8 weeks. Data of maximum speed and time from tests were used as indicators of performance. Variables related to oxidative stress and antioxidant system were also evaluated. Aerobic training was capable to induce enhancements on animals' exercise performance and on their redox state. Additionally, supplementation improved rats' physical performance on both groups, control and trained. Different improvements between groups on the antioxidant capacity were observed. Nevertheless, considering the ergogenic effect of l-arginine and the lack of all positive adaptations promoted by the exercise training, untrained animals may be more exposed to oxidative damages after the practice of intense exercises.
活性物质在运动表现中具有重要意义，因为它们可以直接调节能量产生、肌肉收缩、炎症和疲劳。因此，氧化还原控制对运动员的表现至关重要。研究表明，L-精氨酸在尿素合成、细胞生长和一氧化氮产生中具有重要作用，此外，有迹象表明它还能够通过上调一些抗氧化酶以及抑制活性物质产生的某些途径，对肌肉抗氧化系统产生有益影响。因此，本研究的目的是评估补充L-精氨酸对接受单次高强度运动的雄性大鼠（无论是否训练）的运动表现和氧化应激的影响。40只雄性Wistar大鼠被分为四组，对照组（C）、对照组+L-精氨酸（C + A）、训练组（T）和训练组+L-精氨酸（T + A）。进行了8周的有氧训练。测试中的最大速度和时间数据用作运动表现指标。还评估了与氧化应激和抗氧化系统相关的变量。有氧训练能够提高动物的运动表现及其氧化还原状态。此外，补充剂改善了对照组和训练组大鼠的身体表现。观察到两组之间抗氧化能力的不同改善情况。然而，考虑到L-精氨酸的促力效应以及运动训练所带来的所有积极适应性的缺乏，未经训练的动物在进行剧烈运动后可能更容易受到氧化损伤。
