Mazurenko N N, Seniuta N B, Gladkova T I, Mazurenko N P
Biull Eksp Biol Med. 1988 Jan;105(1):71-4.
The expression of 8 protooncogenes was examined in different types of murine leukemia induced by Mazurenko virus. C-myc-specific RNA (2, 3 kb and 1.8 kb) was revealed only in tissues of mice with thymomas (T-cell leukemias) but not with generalized leukemias. 1.4 kb Ha-ras RNA transcripts were observed in all RNA species from leukemic mice. The highest expression of the above oncogenes was noted in thymus and lymph nodes, in spleen and liver the expression was lower. Ki-ras, abl, fos, myb, erb and B-lym-specific RNA expression was not observed in any of the tissues tested. The expression of C-myc RNA is believed to be the result of C-myc activation due to provirus integration.
检测了马祖连科病毒诱导的不同类型小鼠白血病中8种原癌基因的表达情况。仅在患有胸腺瘤（T细胞白血病）的小鼠组织中检测到C-myc特异性RNA（2.3 kb和1.8 kb），而在全身性白血病小鼠组织中未检测到。在白血病小鼠的所有RNA样本中均观察到1.4 kb的Ha-ras RNA转录本。上述原癌基因在胸腺和淋巴结中的表达最高，在脾脏和肝脏中的表达较低。在所检测的任何组织中均未观察到Ki-ras、abl、fos、myb、erb和B-lym特异性RNA的表达。C-myc RNA的表达被认为是前病毒整合导致C-myc激活的结果。
