Chmielowska J, Stewart M G, Bourne R C
Brain Research Group, Open University, Milton Keynes, U.K.
Brain Res. 1987 Nov 10;425(2):283-9. doi: 10.1016/0006-8993(87)90511-7.
The distribution of high-affinity gamma-aminobutyric acid (GABA) receptors in mouse posteromedial barrel subfield (PMBSF) in layer IV of the somatosensory (SI) cortex was studied using [3H]muscimol autoradiography in vitro. A qualitative study revealed a heterogeneous distribution in the density of [3H]muscimol binding in the barrel field. In the barrel sides and septum between the barrels [3H]muscimol binding exhibits the lowest level of labelling in the entire tissue. In comparison, [3H]muscimol binding in the hollows is considerably higher than in the barrel sides although the level is not homogeneous. These findings suggest that the barrel hollows are much richer in GABA receptors than the surrounding barrel sides and septa.
利用[3H]蝇蕈醇体外放射自显影技术，研究了小鼠体感皮层（SI）第IV层后内侧桶状亚区（PMBSF）中高亲和力γ-氨基丁酸（GABA）受体的分布。定性研究显示，桶状区[3H]蝇蕈醇结合密度分布不均一。在桶壁侧面和桶间间隔处，[3H]蝇蕈醇结合在整个组织中显示出最低的标记水平。相比之下，虽然水平不均一，但空洞中的[3H]蝇蕈醇结合明显高于桶壁侧面。这些发现表明，桶状空洞中的GABA受体比周围的桶壁侧面和间隔丰富得多。
