从肉桂树皮中分离得到的两种新的香叶基苯乙酸苷。
Two new geranylphenylacetate glycosides from the barks of Cinnamomum cassia.
作者信息
Zeng Jun-Fen, Zhu Hu-Cheng, Lu Jian-Wu, Hu Lin-Zhen, Song Jin-Chun, Zhang Yong-Hui
机构信息
a Department of Pharmacy , Renmin Hospital of Wuhan University , Wuhan , China.
b Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, School of Pharmacy , Tongji Medical College, Huazhong University of Science and Technology , Wuhan , China.
出版信息
Nat Prod Res. 2017 Aug;31(15):1812-1818. doi: 10.1080/14786419.2017.1294175. Epub 2017 Mar 6.
Two new glycosides, cinnacassides F (1) and G (2), with a rare geranylphenylacetate carbon skeleton, were isolated from the barks of Cinnamomum cassia, along with three known analogues, cinnacassides A (3), B (4) and C (5). The structures of the new compounds were elucidated on the basis of extensive NMR spectroscopic analyses and chemical method. Compounds 1-5 were investigated for their immunomodulatory activities, and compounds 1, 3 and 4 showed differential immunosuppressive activities against murine lymphocytes.
从肉桂树皮中分离出两种具有罕见香叶基苯乙酸碳骨架的新糖苷，肉桂糖苷F（1）和G（2），以及三种已知类似物，肉桂糖苷A（3）、B（4）和C（5）。通过广泛的核磁共振光谱分析和化学方法阐明了新化合物的结构。对化合物1-5的免疫调节活性进行了研究，化合物1、3和4对小鼠淋巴细胞表现出不同的免疫抑制活性。
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