Li Cuibai, Li Ningxin, Yue Jiarui, Song Qishi, Fan Qingfei
a Key Laboratory of Tropical Plant Resources and Sustainable Use, Xishuangbanna Tropical Botanical Garden , Chinese Academy of Sciences , Kunming , P.R. China.
b Department of medical , Dehong Vocational College , Dehong , P.R. China.
Nat Prod Res. 2017 Jul;31(14):1598-1603. doi: 10.1080/14786419.2017.1286483. Epub 2017 Feb 6.
Two new lignans, (Z)-14-bis(3',4'-dimethoxyphenyl)-2,3-dimethylbut-2-ene-1,4-dione (1), threo-2-methyl-3-oxo-1-(3',4',5'-trimethoxyphenyl)butyl-3″,4″-dimethoxybenzoate (2), together with 15 known derivatives (3-17) were isolated from Saururus chinensis. Their structures were determined on the basis of spectral data, including 1D and 2D NMR experiments and HREIMS spectra. The antitumour activity was screened by MTT assay, compounds 1, 2, 3, 5, 9-11 and 13-15 showed no cytotoxic activity against HL-60, SMMC-7721, A549, MCF-7 and SW480 cell lines.
从三白草中分离得到两个新的木脂素，(Z)-14-双(3',4'-二甲氧基苯基)-2,3-二甲基丁-2-烯-1,4-二酮(1)，苏式-2-甲基-3-氧代-1-(3',4',5'-三甲氧基苯基)丁基-3″,4″-二甲氧基苯甲酸酯(2)，以及15个已知衍生物(3-17)。通过光谱数据，包括一维和二维核磁共振实验以及高分辨电子轰击电离质谱确定了它们的结构。采用MTT法筛选抗肿瘤活性，化合物1、2、3、5、9-11和13-15对HL-60、SMMC-7721、A549、MCF-7和SW480细胞系均无细胞毒性活性。
