Zhang Shui-Mei, Hu Kun, Li Xiao-Nian, Sun Han-Dong, Puno Pema-Tenzin
State Key Laboratory of Phytochemistry and Plant Resources in West China, Yunnan Key Laboratory of Natural Medicinal Chemistry, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming, 650201, People's Republic of China.
University of Chinese Academy of Sciences, Beijing, 10039, People's Republic of China.
Nat Prod Bioprospect. 2022 May 13;12(1):19. doi: 10.1007/s13659-022-00342-3.
A pair of new tetrahydrofuran lignan enantiomers, (±)-schibiculatin A [(±)-1], a new enedione lignan, schibiculatin B (2), two new cadinane-type sesquiterpenoids, schibiculatins C (3) and D (4), along with two known seco-cadinane-type sesquiterpenoids (5 and 6) and seven known miscellaneous lignans (7-13) were isolated from the stems of Schisandra bicolor var. tuberculate. The structures of 1-4 were elucidated by comprehensive analysis of their spectroscopic data, quantum chemical calculations, as well as single-crystal X-ray diffraction. A few isolated compounds were tested for their protective activities against corticosterone-induced apoptosis in PC12 cells. Among them, compounds 5 and 6 showed moderate activities.
从五味子变种瘤枝五味子的茎中分离出一对新的四氢呋喃木脂素对映体，即(±)-schibiculatin A [(±)-1]、一种新的烯二酮木脂素schibiculatin B (2)、两种新的杜松烷型倍半萜schibiculatins C (3)和D (4)，以及两种已知的裂环杜松烷型倍半萜(5和6)和七种已知的其他木脂素(7 - 13)。通过对其光谱数据、量子化学计算以及单晶X射线衍射的综合分析，阐明了1 - 4的结构。对一些分离得到的化合物进行了抗皮质酮诱导的PC12细胞凋亡的保护活性测试。其中，化合物5和6表现出中等活性。
