Mandawat Anant, Williams Andrew E, Francis Sanjeev A
Division of Cardiovascular Medicine, Duke University School of Medicine, 2301 Erwin Road, Durham, NC 27710, USA.
Division of Health Services Research, Center for Outcomes Research and Evaluation, Maine Medical Center Research Institute, 509 Forest Avenue, Suite 200, Portland, MW 04101, USA.
Heart Fail Clin. 2017 Apr;13(2):403-408. doi: 10.1016/j.hfc.2016.12.010.
Despite its challenges, a "big data" approach offers a unique opportunity within the field of cardio-oncology. A pharmacovigilant approach using large data sets can help characterize cardiovascular toxicities of the rapidly expanding armamentarium of targeted therapies. Creating a broad coalition of data sharing can provide insights into the incidence of cardiotoxicity and stimulate research into the underlying mechanisms. Population health necessitates the use of big data and can help inform public health interventions to prevent both cancer and cardiovascular disease. As a relatively new discipline, cardio-oncology is poised to take advantage of big data.
尽管存在挑战,但“大数据”方法在心脏肿瘤学领域提供了一个独特的机会。使用大型数据集的药物警戒方法有助于描述快速扩展的靶向治疗药物库的心血管毒性特征。建立一个广泛的数据共享联盟可以深入了解心脏毒性的发生率,并推动对潜在机制的研究。人群健康需要使用大数据,并有助于为预防癌症和心血管疾病的公共卫生干预措施提供信息。作为一门相对较新的学科,心脏肿瘤学有望利用大数据。