Metabolic and Biomolecular Engineering National Research Laboratory, Department of Chemical and Biomolecular Engineering (BK21 Plus Program), BioProcess Engineering Research Center, Center for Systems and Synthetic Biotechnology, Institute for the BioCentury, KAIST, Daejeon, Republic of Korea; College of Food Science and Engineering, Ocean University of China, Qingdao, People's Republic of China.
College of Food Science and Engineering, Ocean University of China, Qingdao, People's Republic of China.
Biotechnol Adv. 2017 Dec;35(8):1004-1021. doi: 10.1016/j.biotechadv.2017.03.001. Epub 2017 Mar 6.
Many marine bioactive compounds have medicinal and nutritional values. These bioactive compounds have been prepared using solvent-based extraction from marine bio-resources or chemical synthesis, which are costly, inefficient with low yields, and environmentally unfriendly. Recent advances in metabolic engineering allowed to some extent more efficient production of these compounds, showing promises to meet the increasing demand of marine natural bioactive compounds. In this paper, we review the strategies and statuses of metabolic engineering applied to microbial production of marine natural bioactive compounds including terpenoids and their derivatives, omega-3 polyunsaturated fatty acids, and marine natural drugs, and provide perspectives.
许多海洋生物活性化合物具有药用和营养价值。这些生物活性化合物是通过从海洋生物资源中提取溶剂或化学合成制备的，但这些方法成本高、效率低、产量低，而且对环境不友好。代谢工程的最新进展在一定程度上允许更有效地生产这些化合物，有望满足对海洋天然生物活性化合物不断增长的需求。本文综述了代谢工程在微生物生产海洋天然生物活性化合物方面的策略和现状，包括萜类化合物及其衍生物、ω-3 多不饱和脂肪酸和海洋天然药物，并提供了一些展望。
