Ding Zhijie, Joy Marion, Kameneva Marina V, Roy Partha
Department of Bioengineering.
Department of Bioengineering; Department of Surgery; McGowan Institute of Regenerative Medicine.
Breast Cancer (Dove Med Press). 2017 Feb 24;9:61-65. doi: 10.2147/BCTT.S128777. eCollection 2017.
Metastasis is the leading cause of cancer mortality. Extravasation of cancer cells is a critical step of metastasis. We report a novel proof-of-concept study that investigated whether non-toxic blood-soluble chemical agents capable of rheological modification of the near-vessel-wall blood flow can reduce extravasation of tumor cells and subsequent development of metastasis. Using an experimental metastasis model, we demonstrated that systemic administration of nanomolar concentrations of so-called drag-reducing polymer dramatically impeded extravasation and development of pulmonary metastasis of breast cancer cells in mice. This is the first proof-of-principle study to directly demonstrate physical/rheological, as opposed to chemical, way to prevent cancer cells from extravasation and developing metastasis and, thus, it opens the possibility of a new direction of adjuvant interventional approach in cancer.
转移是癌症死亡的主要原因。癌细胞外渗是转移的关键步骤。我们报告了一项新颖的概念验证研究，该研究调查了能够对近血管壁血流进行流变学修饰的无毒血液可溶性化学试剂是否可以减少肿瘤细胞的外渗及随后转移的发生。使用实验性转移模型，我们证明了全身给予纳摩尔浓度的所谓减阻聚合物可显著阻碍小鼠体内乳腺癌细胞的外渗和肺转移的发生。这是第一项直接证明通过物理/流变学（而非化学）方法防止癌细胞外渗和发生转移的原理验证研究，因此，它为癌症辅助介入方法开辟了一个新方向的可能性。
