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维生素K缺乏症在一名患有前纵隔肿块的婴儿中的表现：病例报告及文献综述

Vitamin K Deficiency Presenting in an Infant with an Anterior Mediastinal Mass: A Case Report and Review of the Literature.

作者信息

Palau Mauricio A, Winters Amanda, Liang Xiayuan, Nuss Rachelle, Niermeyer Susan, Gossling Megan, Wright Clyde

机构信息

School of Medicine, University of Colorado, Boulder, CO, USA.

出版信息

Case Rep Pediatr. 2017;2017:7628946. doi: 10.1155/2017/7628946. Epub 2017 Feb 9.

DOI:10.1155/2017/7628946
PMID:28280644
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5322422/
Abstract

We report a case of a 1-month-old infant with spontaneous thymic hemorrhage secondary to severe vitamin K deficiency. He was brought to medical attention due to scrotal bruising and during evaluation was noted to be tachypneic and hypoxemic. Chest X-ray revealed an enlarged cardiothymic silhouette, and a follow-up echocardiogram revealed a mass in the anterior mediastinum. Routine laboratory work-up revealed severe coagulopathy. Further questioning revealed the patient had not received prophylactic vitamin K at birth. The coagulopathy resolved with administration of vitamin K, and a biopsy confirmed the anterior mediastinal mass was due to spontaneous thymic hemorrhage.

摘要

我们报告一例1个月大的婴儿，因严重维生素K缺乏继发自发性胸腺出血。他因阴囊瘀伤就医，评估时发现呼吸急促和低氧血症。胸部X线显示心胸轮廓增大，后续超声心动图显示前纵隔有一肿块。常规实验室检查显示严重凝血障碍。进一步询问发现该患者出生时未接受维生素K预防治疗。给予维生素K后凝血障碍得到缓解，活检证实前纵隔肿块是由自发性胸腺出血所致。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4800/5322422/441f1facdf25/CRIPE2017-7628946.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4800/5322422/d5a253194dd6/CRIPE2017-7628946.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4800/5322422/0572573fd831/CRIPE2017-7628946.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4800/5322422/441f1facdf25/CRIPE2017-7628946.003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4800/5322422/d5a253194dd6/CRIPE2017-7628946.001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4800/5322422/0572573fd831/CRIPE2017-7628946.002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/4800/5322422/441f1facdf25/CRIPE2017-7628946.003.jpg

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本文引用的文献

1
Reasons for Refusal of Newborn Vitamin K Prophylaxis: Implications for Management and Education.新生儿维生素K预防措施拒绝原因：对管理和教育的启示
Hosp Pediatr. 2016 Jan;6(1):15-21. doi: 10.1542/hpeds.2015-0095.
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Rise in late onset vitamin K deficiency bleeding in young infants because of omission or refusal of prophylaxis at birth.由于出生时未进行预防或预防措施被拒绝，导致幼儿晚发性维生素K缺乏性出血症增多。
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Pediatric thymomas: report of two cases and comprehensive review of the literature.
小儿胸腺瘤：两例报告及文献综述
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Kaposiform lymphangiomatosis: a distinct aggressive lymphatic anomaly.卡波西样淋巴管瘤病：一种独特的侵袭性淋巴异常。
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Anterior mediastinal lymphangioma: pre- and postnatal sonographic findings.
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Vitamin K deficiency bleeding (VKDB) in early infancy.婴儿早期维生素K缺乏性出血（VKDB）
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True thymic hyperplasia associated with severe thymic cyst bleeding in a newborn: case report and review of the literature.新生儿真性胸腺增生伴严重胸腺囊肿出血：病例报告及文献复习
Ann Diagn Pathol. 2007 Oct;11(5):358-62. doi: 10.1016/j.anndiagpath.2006.04.007. Epub 2007 Jul 24.