Jug Rachel, Jiang Xiaoyin
Duke Health, DUMC 3712, Durham, NC 27710, USA.
Patholog Res Int. 2017;2017:1057252. doi: 10.1155/2017/1057252. Epub 2017 Feb 9.
A consensus panel recently used clinical evidence and pathologic parameters to rename noninvasive encapsulated follicular variant of papillary thyroid carcinoma to noninvasive follicular thyroid neoplasm with papillary-like nuclear features (NIFTP) to better reflect the indolent course of this tumor. NIFTP has stringent histopathologic diagnostic criteria established by the panel, including papillary-like nuclear features, and submission of the entire tumor capsule to exclude invasion. From a molecular standpoint, NIFTP is often characterized by RAS-type mutations, similar to other follicular-patterned lesions. While there has been prior evidence in the literature for the low malignant potential of these tumors, projects moving forward will help to independently reinforce the reliability of these criteria and nomenclature. With planned inclusion of NIFTP into the latest World Health Organization endocrine tumor classification scheme, this nomenclature shift provides a model for pathology efforts to refine diagnostic classifications to better guide treatment. In this review we discuss this nomenclature change and review the current literature.
一个共识小组最近利用临床证据和病理参数，将甲状腺乳头状癌的非侵袭性包膜滤泡型更名为具有乳头状核特征的非侵袭性滤泡性甲状腺肿瘤（NIFTP），以更好地反映该肿瘤的惰性病程。NIFTP有该小组制定的严格组织病理学诊断标准，包括乳头状核特征，以及提交整个肿瘤包膜以排除浸润。从分子角度来看，NIFTP通常具有RAS型突变特征，这与其他滤泡型病变类似。虽然此前文献中有证据表明这些肿瘤的恶性潜能较低，但未来的研究项目将有助于独立强化这些标准和命名的可靠性。随着计划将NIFTP纳入最新的世界卫生组织内分泌肿瘤分类方案，这种命名转变为病理学改进诊断分类以更好地指导治疗提供了一个范例。在本综述中，我们讨论了这一命名变化并回顾了当前的文献。
