College of Life Sciences, College of Chemistry and Materials Science, Jiangsu Key Laboratory of Biofunctional Materials, Jiangsu Collaborative Innovation Centre of Biomedical Functional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing, 210023, P. R. China.
Dalton Trans. 2017 Apr 19;46(16):5151-5158. doi: 10.1039/c7dt00489c.
A facile and robust one-pot approach to prepare a theranostic nanoplatform, based on chelation between Gd and hypericin photosensitizer (PS) and their controlled in situ hydrolysis precipitation, was developed. In this strategy, PS drugs and Gd were directly used as building blocks to construct theranostic nanoparticles, resulting in a greatly increased active substance-loading efficiency and ensuring their theranostic effect. The resulting nanoparticles have multifunction capabilities for nuclear magnetic resonance (NMR) imaging and anticancer activity through adenosine triphosphate (ATP) deprivation and heavy atom effect (HAE)-improved photodynamic therapy (PDT) mechanisms.
一种基于钆与hypericin 光敏剂（PS）螯合及其原位水解沉淀的简便、稳健的一锅法被开发用于制备治疗一体化纳米平台。在此策略中，PS 药物和 Gd 直接用作构建治疗一体化纳米颗粒的构建块，从而极大地提高了有效物质的负载效率，并确保了它们的治疗效果。所得纳米颗粒通过三磷酸腺苷（ATP）剥夺和重原子效应（HAE）增强的光动力治疗（PDT）机制，具有磁共振成像（NMR）和抗癌活性的多功能能力。
