一种用于癌症靶向光动力治疗和磷光成像的仿生治疗 O 计。
A biomimetic theranostic O-meter for cancer targeted photodynamic therapy and phosphorescence imaging.
机构信息
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, China; Key Laboratory of Molecular Clinical Pharmacology, School of Pharmaceutical Sciences, Guangzhou Medical University, Guangzhou, 511436, China.
Key Laboratory of Biomedical Polymers of Ministry of Education & Department of Chemistry, Wuhan University, Wuhan, 430072, China.
出版信息
Biomaterials. 2018 Jan;151:1-12. doi: 10.1016/j.biomaterials.2017.10.021. Epub 2017 Oct 12.
In this report, a biomimetic theranostic oxygen (O)-meter (cancer cell membrane@Pt(II) porphyrinic-metal organic framework, designated as mPPt) was constructed for cancer targeted and phosphorescence image-guided photodynamic therapy (PDT). mPPt presents high photosensitizers (PSs) loading and evitable self-quenching behaviors for favorable biological O sensing and PDT. Besides, endowed by the surface functionalization of cancer cell membrane, the homotypic targeting and immune escape abilities of mPPt could dramatically enhance its cancer targeting ability. Importantly, the O-dependent phosphorescence responsibility of mPPt could be employed to pre-evaluate the real time O level in situ and guide the PDT under light irradiation. A significant anticancer effect is observed after intravenous injection of mPPt and subsequent treatment with PDT with no obvious side effects. As a versatile platform for cell imaging, O fluctuation monitoring as well as PDT, this biomimetic O-meter exhibits great potential for biological analysis and personalized cancer theranostics.
在本报告中，构建了一种仿生治疗性氧（O）计（癌细胞膜@Pt(II) 卟啉金属有机骨架，命名为 mPPt），用于癌症靶向和磷光图像引导光动力治疗（PDT）。mPPt 具有高的光敏剂（PS）负载和可避免的自猝灭行为，有利于生物 O 传感和 PDT。此外，得益于癌细胞膜的表面功能化，mPPt 的同型靶向和免疫逃逸能力可以显著增强其癌症靶向能力。重要的是，mPPt 的 O 依赖性磷光响应性可以用于原位实时评估 O 水平，并在光照射下指导 PDT。静脉注射 mPPt 并随后进行 PDT 治疗后，观察到显著的抗癌效果，没有明显的副作用。作为细胞成像、O 波动监测和 PDT 的多功能平台，这种仿生 O 计在生物分析和个性化癌症治疗方面具有巨大的潜力。
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