College of Chemistry and Materials Science, Analysis and Testing Center, Jiangsu Key Laboratory Biofunctional Materials, Key Laboratory of Applied Photochemistry, Nanjing Normal University, Nanjing 210023, PR China.
Bioorg Med Chem Lett. 2013 Oct 1;23(19):5317-24. doi: 10.1016/j.bmcl.2013.07.064. Epub 2013 Aug 6.
Hypocrellin A (HA), an a natural perylene quinine photosensitizers (PSs), can chelate with heavy metal ions, including Au(III) and Pt(IV), to form a 1:2 complex, which exhibits enhanced (1)O2 generation quantum yield through the increased intersystem crossing efficiency mediated by internal heavy atom effect. Besides, the chelate process greatly improved the water solubility of HA. Comparative studies with HA and complexes have demonstrated that the heavy-atom effect on HA molecules enhances the efficiency of in vitro photodynamic (PDT) efficacy.
竹红菌素 A（HA）是一种天然的萘醌类光敏剂（PS），可以与包括金（III）和铂（IV）在内的重金属离子螯合，形成 1:2 的配合物，通过内部重原子效应介导的增加系间穿越效率来提高（1）O2 生成量子产率。此外，螯合过程极大地提高了 HA 的水溶性。与 HA 和配合物的比较研究表明，重原子效应对 HA 分子的增强作用提高了体外光动力疗法（PDT）的效率。
