Girlanda P, Muglia U, Vita G, Dattola R, Santoro M, Toscano A, Venuto C, Roberto M L, Baradello A, Romano M
Institute of Neurological and Neurosurgical Sciences, University of Messina, Italy.
Exp Neurol. 1988 Feb;99(2):454-60. doi: 10.1016/0014-4886(88)90162-8.
Crush of sciatic nerve in rabbits supported by morphologic and electrophysiologic data was used to evaluate the effects of ACTH4-10 on nerve fiber regeneration. Treated animals showed a statistically significant higher regeneration rate than did control rabbits. Fiber density and mean diameters of myelinated nerve fibers were measured in semithin nerve sections at 1 and 3 cm distal from the crushed point at three different time points. Nerve fiber density results were higher in ACTH4-10-than in vehicle-treated rabbits. This difference showed an unequivocal trend and attained a statistically significant level in the sections 3 cm distal from the crush. ACTH4-10 seemed therefore to have a beneficial effect on nerve fiber regeneration.
利用兔坐骨神经挤压伤模型，并结合形态学和电生理学数据，评估促肾上腺皮质激素4-10（ACTH4-10）对神经纤维再生的影响。与对照兔相比，接受治疗的动物的神经再生率具有统计学意义上的显著提高。在三个不同时间点，于距挤压点远端1厘米和3厘米处的半薄神经切片中测量有髓神经纤维的纤维密度和平均直径。ACTH4-10治疗组兔的神经纤维密度结果高于载体治疗组。这种差异呈现出明确的趋势，并在距挤压点远端3厘米处的切片中达到统计学显著水平。因此，ACTH4-10似乎对神经纤维再生具有有益作用。
