Carlström K, Bergqvist A, Ljungberg O
Department of Obstetrics and Gynecology, Karolinska Institutet, Huddinge University Hospital, Sweden.
Fertil Steril. 1988 Feb;49(2):229-33. doi: 10.1016/s0015-0282(16)59707-6.
The metabolism of [3H]estrone sulfate (E1S) into [3H]estrone (E1) and [3H]estradiol-17 beta (E2) was studied in samples of endometriotic tissue and uterine endometrium obtained simultaneously from 13 patients, 7 in the proliferative and 5 in the secretory cycle phase, and 1 menstruating. E1S was efficiently converted into E1 and E2 by both types of tissue. Total hydrolysis (formation of E1 + E2), as well as the specific formation of E2, was higher in uterine endometrium than in endometriotic tissue, especially in the proliferative phase. Cycle phase associated variations in E2 formation occurred in both tissues, but were statistically significant only for uterine endometrium. E2 formation and total hydrolysis were correlated in endometriotic tissue, but not in uterine endometrium, indicating certain differences in the regulation of estrogen metabolism.
在同时取自13例患者的子宫内膜异位组织和子宫内膜样本中研究了[3H]硫酸雌酮（E1S）向[3H]雌酮（E1）和[3H]雌二醇-17β（E2）的代谢情况，其中7例处于增殖期，5例处于分泌期，1例处于月经期。两种组织均可将E1S有效转化为E1和E2。子宫内膜中E1S的总水解（生成E1 + E2）以及E2的特异性生成均高于子宫内膜异位组织，尤其是在增殖期。两种组织中均出现了与周期阶段相关的E2生成变化，但仅子宫内膜的变化具有统计学意义。子宫内膜异位组织中E2生成与总水解相关，而子宫内膜中则不相关，这表明雌激素代谢调节存在某些差异。
