来自琴叶珊瑚的具有硫氧还蛋白还原酶抑制活性的二萜类化合物。
Diterpenoids with thioredoxin reductase inhibitory activities from Jatropha multifida.
作者信息
Zhu Jian-Yong, Zhang Chun-Yang, Dai Jing-Jing, Rahman Khalid, Zhang Hong
机构信息
a Central Laboratory , Seventh People's Hospital of Shanghai University of TCM , Shanghai , P. R. China.
b School of Pharmacy , Chengdu University of Traditional Chinese Medicine , Chengdu , P. R. China.
出版信息
Nat Prod Res. 2017 Dec;31(23):2753-2758. doi: 10.1080/14786419.2017.1297441. Epub 2017 Mar 10.
Chemical investigation of the Jatropha multifida has led to the isolation of nine diterpenoids (1-9), including a new jatromulone A, four podocarpane diterpenoids (2-5), two lathyrane-type diterpenoids (6 and 7) and two dinorditerpenoids (8 and 9). Their structures were elucidated by spectroscopic analysis, and the absolute configurations of 1 were determined by CD analysis. All of the diterpenoids were screened for inhibitory activity against thioredoxin reductase (TrxR), which is a potential target for cancer chemotherapy with redox balance and antioxidant functions. Compounds 6 and 7 exhibited stronger activity (IC: 23.4 and 10.6 μM, respectively) than the positive control, curcumin (IC = 25.0 μM). Compounds 2-9 were isolated from J. multifida for the first time.
对珊瑚花的化学研究已导致分离出九种二萜类化合物（1-9），包括一种新的麻风树酮A、四种罗汉松烷二萜类化合物（2-5）、两种山黧豆烷型二萜类化合物（6和7）以及两种去甲二萜类化合物（8和9）。通过光谱分析阐明了它们的结构，并通过圆二色性分析确定了1的绝对构型。对所有二萜类化合物进行了针对硫氧还蛋白还原酶（TrxR）的抑制活性筛选，硫氧还蛋白还原酶是具有氧化还原平衡和抗氧化功能的癌症化疗潜在靶点。化合物6和7表现出比阳性对照姜黄素（IC = 25.0 μM）更强的活性（IC分别为23.4和10.6 μM）。化合物2-9首次从珊瑚花中分离得到。
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