从麻疯树中提取的新生物活性大环二萜。

New bioactive macrocyclic diterpenoids from Jatropha multifida.

机构信息

Organic Chemistry Division-I, Indian Institute of Chemical Technology, Hyderabad 500 607, India.

出版信息

Bioorg Med Chem Lett. 2011 Nov 15;21(22):6808-10. doi: 10.1016/j.bmcl.2011.09.032. Epub 2011 Sep 22.

DOI:10.1016/j.bmcl.2011.09.032

PMID:21996519

Abstract

Two new macrocyclic diterpenoids, multifidanol (1) and multifidenol (2) along with several known compounds have been isolated from the stem of Jatropha multifida. The structures of the new compounds were established from the extensive studies of their 1D and 2D NMR spectra. The cytotoxic and antimicrobial activities of these two constituents were examined.

摘要

从麻疯树的茎中分离得到了两个新的大环二萜类化合物，即麻疯树醇（1）和麻疯树醇（2）以及几种已知化合物。通过对它们的 1D 和 2D NMR 光谱的广泛研究，确定了这两个新化合物的结构。对这两种成分的细胞毒性和抗菌活性进行了检测。