School of Pharmaceutical Sciences, Sun Yat-sen University, Guangzhou 510006, China.
Institute of Traditional Chinese Medicine and Natural Products, College of Pharmacy, Jinan University, Guangzhou 510632, China.
Chin J Nat Med. 2019 Apr;17(4):298-302. doi: 10.1016/S1875-5364(19)30033-0.
Jatrogricaine A (1), a new diterpenoid possessing a 5/6/6/4 carbon ring system, together with eight known diterpenoids (2-9) were isolated from the stems of Jatropha podagrica. Their structures were elucidated by extensive spectroscopic methods and the absolute configuration of 1 was determined by single crystal X-ray diffraction analysis. All compounds were evaluated for their anti-inflammatory activities in vitro, and compound 3 showed significant inhibitory effects against nitric oxide (NO) production in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells with an IC of 13.44 ± 0.28 μmol·L, being comparable to the positive control, quercetin (IC 17.00 ± 2.10 μmol·L).
Jatrogricaine A（1），一种具有 5/6/6/4 个碳原子环系统的新二萜类化合物，与八种已知的二萜类化合物（2-9）一起从 Jatropha podagrica 的茎中分离出来。通过广泛的光谱方法阐明了它们的结构，并且通过单晶 X 射线衍射分析确定了 1 的绝对构型。所有化合物均在体外进行了抗炎活性评估，化合物 3 对脂多糖（LPS）诱导的 RAW264.7 巨噬细胞中一氧化氮（NO）的产生表现出显著的抑制作用，IC 为 13.44 ± 0.28 μmol·L，与阳性对照槲皮素（IC 17.00 ± 2.10 μmol·L）相当。
