来自海洋放线菌诺卡氏菌属菌株YIM M13066的α-吡喃酮衍生物
α-pyrone derivatives from a marine actinomycete Nocardiopsis sp. YIM M13066.
作者信息
Zhang Xiao-Mei, Sun Ming-Wei, Shi Hui, Lu Chun-Hua
机构信息
b College of Basic Medicine , Yunnan University of Traditional Chinese Medicine , Kunming , China.
a Key Laboratory of Chemical Biology (Ministry of Education), School of Pharmaceutical Sciences , Shandong University , Jinan , China.
出版信息
Nat Prod Res. 2017 Oct;31(19):2245-2249. doi: 10.1080/14786419.2017.1299730. Epub 2017 Mar 10.
Five new α-pyrones namely nocapyrones O-S (2-6) and nocapyrone F (1) were isolated from a deep-sea sediment strain Nocardiopsis sp. YIM M13066. Their structures were elucidated by their NMR spectroscopic data, HR-ESI-MS and crystal X-ray diffraction. Their cytotoxic activities against H1299, HeLa, HL7702, MCF-7, PC3 and U251 cell lines were evaluated.
从深海沉积物菌株诺卡氏菌属（Nocardiopsis sp.）YIM M13066中分离出了5种新的α-吡喃酮，即诺卡吡喃酮O-S（2-6）和诺卡吡喃酮F（1）。通过核磁共振光谱数据、高分辨电喷雾电离质谱和晶体X射线衍射对它们的结构进行了阐明。评估了它们对H1299、HeLa、HL7702、MCF-7、PC3和U251细胞系的细胞毒性活性。
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