Zou Ge, Liao Xiao-Jian, Peng Qi, Chen Guo-Dong, Wei Fang-Ying, Xu Zheng-Xiong, Zhao Bing-Xin, Xu Shi-Hai
a Department of Chemistry , Jinan University , Guangzhou 510632 , China.
b College of Pharmacy, Jinan University , Guangzhou 510632 , China.
J Asian Nat Prod Res. 2017 Dec;19(12):1232-1238. doi: 10.1080/10286020.2017.1307186. Epub 2017 Mar 28.
A new α-pyrone, nocapyrone S (1), together with five known compounds (2-6), were isolated from the deep-sea actinomycete Nocardiopsis dassonvillei subsp. dassonvillei DSM 43111(T). Their structures were determined by spectroscopic analyses. The absolute configuration of 1 was established by quantum approaches. Cytotoxic activity of 1 was evaluated against K562, MCF-7, SGC7901, A375, Hela, and HepG2 cell lines.
从深海放线菌达松维尔诺卡氏菌亚种达松维尔诺卡氏菌DSM 43111(T)中分离出一种新的α-吡喃酮诺卡吡喃酮S (1)以及五种已知化合物(2 - 6)。通过光谱分析确定了它们的结构。通过量子方法确定了1的绝对构型。评估了1对K562、MCF-7、SGC7901、A375、Hela和HepG2细胞系的细胞毒性活性。
