Cetin Orkun, Karaman Erbil, Boza Baris, Cim Numan, Alisik Murat, Erel Ozcan, Kolusarı Ali, Sahin Hanım Guler
a Department of Obstetrics and Gynecology, Faculty of Medicine , Yuzuncu Yil University , Van , Turkey.
b Department of Biochemistry, Faculty of Medicine , Yıldırım Beyazıt University , Ankara , Turkey.
J Matern Fetal Neonatal Med. 2018 Mar;31(5):607-613. doi: 10.1080/14767058.2017.1293025. Epub 2017 Feb 28.
To investigate the maternal serum thiol/disulfide homeostasis in pregnancies complicated by idiopathic intrauterine growth restriction (IUGR) and to compare the results with healthy pregnancies.
This descriptive cohort study included 55 pregnant women complicated by idiopathic IUGR and 57 similar gestational aged healthy pregnant women in the third trimester of gestation. Maternal serum samples were collected at the day of diagnosis and the thiol/disulfide homeostasis was measured by using an automated assay method. The patients were followed up until delivery and perinatal outcomes were recorded.
Maternal serum native thiol (308.1 ± 40.7 μmol/L vs. 282.4 ± 60.6 μmol/L) and total thiol (346.8 ± 48.1 μmol/L vs. 324.0 ± 62.2 μmol/L) concentrations were significantly lower in IUGR group compared with healthy controls (p: .010 and p: .032, respectively), whereas disulfide (19.3 ± 8.7 μmol/L vs. 20.8 ± 7.8 μmol/L) concentrations were similar between the groups (p: .350). Maternal serum disulfide/native thiol and disulfide/total thiol ratios were higher in IUGR group compared with healthy controls (p: .014 and p: .017, respectively), whereas native thiol/total thiol ratio was significantly lower in IUGR group compared with healthy controls (p: .016).
This study suggests that there is an impaired maternal thiol/disulfide homeostasis in pregnancies complicated by idiopathic IUGR during the third trimester of gestation.
研究合并特发性宫内生长受限（IUGR）的妊娠孕妇血清中硫醇/二硫化物的稳态，并将结果与健康妊娠孕妇进行比较。
这项描述性队列研究纳入了55例合并特发性IUGR的孕妇以及57例孕晚期孕周相似的健康孕妇。在诊断当天采集孕妇血清样本，采用自动检测方法测定硫醇/二硫化物的稳态。对患者进行随访直至分娩，并记录围产期结局。
与健康对照组相比，IUGR组孕妇血清天然硫醇（308.1±40.7μmol/L对282.4±60.6μmol/L）和总硫醇（346.8±48.1μmol/L对324.0±62.2μmol/L）浓度显著降低（p值分别为0.010和0.032），而两组间二硫化物浓度相似（19.3±8.7μmol/L对20.8±7.8μmol/L，p值为0.350）。与健康对照组相比，IUGR组孕妇血清二硫化物/天然硫醇和二硫化物/总硫醇比值更高（p值分别为0.014和0.017），而IUGR组天然硫醇/总硫醇比值显著低于健康对照组（p值为0.016）。
本研究表明，在妊娠晚期合并特发性IUGR的孕妇中，其母体硫醇/二硫化物稳态受损。
