原位记忆T细胞和侵袭模式可预测早期口腔鳞状细胞癌患者的预后。
In situ memory T cells and patterns of invasion predict outcome in patients with early-stage oral squamous cell carcinoma.
作者信息
Wang Shan, Xu Jiankai, Meng Yan, Qiang Dongxia, Sun Changsheng, Shi Lei, Zhao Eryang
机构信息
Department of Oral Pathology, Hospital of Stomatology, the First Affiliated Hospital, Harbin Medical University, Harbin 150001, Heilongjiang, China.
College of Bioinformatics Science and Technology, Harbin Medical University, Harbin 150081, Heilongjiang, China.
出版信息
Cancer Biomark. 2017;19(2):199-205. doi: 10.3233/CBM-160512.
PURPOSE
The objective of this study was to explore the prognostic value of in situ memory T cells and patterns of invasion (POI) in early stage oral squamous cell carcinoma (OSCC).
METHODS
One hundred fifty-seven patients with early stage (cT1T2N0) OSCC were identified from a pre-existing database of patients with oral cancer and were classified by POI according to hematoxylin-eosin staining. We examined the impact of the immunohistochemical expression of CD45RO in OSCC. Overall survival (OS) curves were calculated using the Kaplan-Meier method.
RESULTS
Margin status was significantly associated with local recurrence in early stage OSCC (p= 0.000), and depth of invasion was also associated with regional recurrence (2 mm: p= 0.034; 4 mm: p= 0.015). The expression of CD45RO (p= 0.021) and POI (p= 0.027) individually was associated with OS, and patients in the group with combination score tended to have worse OS (p= 0.012).
CONCLUSION
Combined evaluation of POI and CD45RO might prove to be a useful indicator for high-risk patients with occult metastases from early stage OSCC.
目的
本研究的目的是探讨原位记忆T细胞和侵袭模式（POI）在早期口腔鳞状细胞癌（OSCC）中的预后价值。
方法
从一个现有的口腔癌患者数据库中识别出157例早期（cT1T2N0）OSCC患者，并根据苏木精-伊红染色通过POI进行分类。我们检测了OSCC中CD45RO免疫组化表达的影响。使用Kaplan-Meier方法计算总生存（OS）曲线。
结果
切缘状态与早期OSCC的局部复发显著相关（p = 0.000），侵袭深度也与区域复发相关（2mm：p = 0.034；4mm：p = 0.015）。CD45RO（p = 0.021）和POI（p = 0.027）的表达分别与OS相关，联合评分组的患者OS往往更差（p = 0.012）。
结论
POI和CD45RO的联合评估可能被证明是早期OSCC隐匿性转移高危患者的有用指标。
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