Department of Oral Pathology, Hospital of Stomatology, The First Affiliated Hospital, Harbin Medical University, Harbin, 150001, People's Republic of China.
Department of Anatomy, Basic Medical Science College, Harbin Medical University, Harbin, 150081, People's Republic of China.
Clin Oral Investig. 2018 Apr;22(3):1131-1138. doi: 10.1007/s00784-017-2197-9. Epub 2017 Sep 2.
The objective of this study was to explore the prognostic value of cancer stem cell markers, namely CD133, NANOG, and NOTCH1, in early stage oral squamous cell carcinoma (OSCC).
One hundred forty-four patients with early stage (cT1T2N0) OSCC were identified from a pre-existing database of patients with oral cancer. We examined the impact of the immunohistochemical expression of CD133, NANOG, and NOTCH1 in OSCC. Overall survival (OS) curves were calculated using the Kaplan-Meier method. Predictors of outcome were identified using multivariate analysis.
We found that CD133, NANOG, and NOTCH1 were significantly associated with lymph node metastasis, and NOTCH1 was also significantly associated with depth of invasion and locoregional recurrence.
NOTCH1 was identified as an independent prognostic factor for OS.
NOTCH1 might prove to be a useful indicator for high-risk patients with occult metastases from early stage OSCC.
本研究旨在探讨癌症干细胞标志物 CD133、NANOG 和 NOTCH1 在早期口腔鳞状细胞癌（OSCC）中的预后价值。
从口腔癌患者的现有数据库中确定了 144 例早期（cT1T2N0）OSCC 患者。我们检查了 CD133、NANOG 和 NOTCH1 在 OSCC 中的免疫组织化学表达的影响。使用 Kaplan-Meier 方法计算总生存期（OS）曲线。使用多变量分析确定预后的预测因素。
我们发现 CD133、NANOG 和 NOTCH1 与淋巴结转移显著相关，而 NOTCH1 也与浸润深度和局部区域复发显著相关。
NOTCH1 被确定为 OS 的独立预后因素。
NOTCH1 可能被证明是早期 OSCC 隐匿性转移的高危患者的有用指标。
