Hammouda Nada E, Salah El-Din Manal A, El-Shishtawy Mamdouh M, El-Gayar Amal M
Department of Biochemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Oncology Center, Faculty of Medicine, Mansoura University, Mansoura 35516, Egypt.
Sci Pharm. 2017 Mar 8;85(1):9. doi: 10.3390/scipharm85010009.
Elevated serum levels of cystatin C are found to be related to poor outcome and metastatic potential of some malignant disorders. To evaluate the clinical prominence of serum cystatin C in diffuse large B-cell lymphoma (DLBCL), blood samples were obtained from 58 patients at the time of diagnosis and paired blood samples were obtained from 22 patients at the time of remission. Also, serum cystatin C level was measured in matched healthy controls. Serum cystatin C levels were significantly more elevated in DLBCL patients than in controls ( < 0.0001). Furthermore, paired-sample analysis revealed that pretreatment cystatin C levels were reduced significantly in patients who achieved remission after therapy ( = 0.016). High serum cystatin C levels were correlated with age over 60 years ( = 0.049), extra-nodal involvement ( = 0.005) and with high serum lactate dehydrogenase (LDH) ( < 0.013). Elevated serum cystatin C levels were associated with extra-nodal involvement and they were significantly reduced to normal range after the remission. However, Kaplan-Meier curves revealed no survival difference in the pretreatment serum cystatin C levels. Therefore, serum cystatin C may be a novel biomarker that reflects tumor burden in DLBCL but bears no prognostic significance regarding survival.
血清胱抑素C水平升高与某些恶性疾病的不良预后和转移潜能有关。为评估血清胱抑素C在弥漫性大B细胞淋巴瘤（DLBCL）中的临床意义，在诊断时采集了58例患者的血样，并在缓解期采集了22例患者的配对血样。此外，还检测了匹配的健康对照者的血清胱抑素C水平。DLBCL患者的血清胱抑素C水平显著高于对照组（<0.0001）。此外，配对样本分析显示，治疗后缓解的患者治疗前的胱抑素C水平显著降低（=0.016）。血清胱抑素C水平高与60岁以上年龄（=0.049）、结外受累（=0.005）以及血清乳酸脱氢酶（LDH）水平高（<0.013）相关。血清胱抑素C水平升高与结外受累有关，缓解后显著降至正常范围。然而，Kaplan-Meier曲线显示治疗前血清胱抑素C水平在生存方面无差异。因此，血清胱抑素C可能是一种反映DLBCL肿瘤负荷的新型生物标志物，但对生存无预后意义。
