DNA 相互作用的吡咯并[2,1-c][1,4]苯并二氮杂卓（PBDs）的合成。 - Suppr

Synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).

作者信息

Antonow Dyeison, Thurston David E

机构信息

Gene Targeting Drug Design Research Group, The School of Pharmacy, University of London, 29/39 Brunswick Square, London WC1N 1AX, UK.

出版信息

Chem Rev. 2011 Apr 13;111(4):2815-64. doi: 10.1021/cr100120f. Epub 2010 Dec 17.

DOI:10.1021/cr100120f

PMID:21166464

Abstract

摘要

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Synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).DNA 相互作用的吡咯并[2,1-c][1,4]苯并二氮杂卓（PBDs）的合成。

Chem Rev. 2011 Apr 13;111(4):2815-64. doi: 10.1021/cr100120f. Epub 2010 Dec 17.

Fluorescent 7-diethylaminocoumarin pyrrolobenzodiazepine conjugates: synthesis, DNA interaction, cytotoxicity and differential cellular localization.荧光7-二乙氨基香豆素吡咯并苯并二氮杂卓缀合物：合成、与DNA的相互作用、细胞毒性及细胞定位差异

Bioorg Med Chem Lett. 2008 Mar 15;18(6):2147-51. doi: 10.1016/j.bmcl.2008.01.083. Epub 2008 Jan 30.

Synthesis of C8-linked pyrrolo[2,1-c][1,4]benzodiazepine-benzimidazole conjugates with remarkable DNA-binding affinity.具有显著DNA结合亲和力的C8连接的吡咯并[2,1-c][1,4]苯并二氮杂卓-苯并咪唑缀合物的合成。

Bioorg Med Chem Lett. 2004 Sep 20;14(18):4791-4. doi: 10.1016/j.bmcl.2004.06.069.

Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates.吡咯并[2,1-c][1,4]苯并二氮杂卓（PBD）C8环胺缀合物的合成与生物学评价

Bioorg Med Chem Lett. 2004 Feb 23;14(4):901-4. doi: 10.1016/j.bmcl.2003.12.017.

Synthesis and DNA-binding ability of pyrrolo[2,1-c][1,4]benzodiazepine-azepane conjugates.

Bioorg Med Chem Lett. 2006 Mar 1;16(5):1160-3. doi: 10.1016/j.bmcl.2005.11.090. Epub 2005 Dec 19.

(4-Substituted-phenyl)-(5H-10,11-dihydro-pyrrolo [2,1-c][1,4] benzodiazepin-10-yl)-methanone derivatives as vasopressin receptor modulators.

Bioorg Med Chem Lett. 2005 Nov 15;15(22):5003-6. doi: 10.1016/j.bmcl.2005.08.007.

Synthesis and DNA binding affinity of novel A-C8/C-C2-exo unsaturated alkoxyamido-linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.新型A-C8/C-C2-外向不饱和烷氧基酰胺连接的吡咯并[2,1-c][1,4]苯并二氮杂卓二聚体的合成及与DNA的结合亲和力

Bioorg Med Chem. 2004 Aug 15;12(16):4337-50. doi: 10.1016/j.bmc.2004.06.013.

Synthesis, DNA-binding ability and evaluation of antitumour activity of triazolo[1,2,4]benzothiadiazine linked pyrrolo[2,1-c][1,4]benzodiazepine conjugates.三唑并[1,2,4]苯并噻二嗪连接的吡咯并[2,1-c][1,4]苯并二氮杂䓬共轭物的合成、DNA结合能力及抗肿瘤活性评价

Bioorg Med Chem. 2008 Aug 15;16(16):7804-10. doi: 10.1016/j.bmc.2008.06.056. Epub 2008 Jul 3.

Application of the Stille coupling reaction to the synthesis of C2-substituted endo-exo unsaturated pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).施蒂勒偶联反应在C2-取代的内-外不饱和吡咯并[2,1-c][1,4]苯并二氮杂卓（PBDs）合成中的应用。

Bioorg Med Chem Lett. 2004 Oct 18;14(20):5041-4. doi: 10.1016/j.bmcl.2004.08.002.

An asymmetric C8/C8'-tripyrrole-linked sequence-selective pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimer DNA interstrand cross-linking agent spanning 11 DNA base pairs.一种不对称的C8/C8'-三吡咯连接的序列选择性吡咯并[2,1-c][1,4]苯并二氮杂卓（PBD）二聚体DNA链间交联剂，跨度为11个DNA碱基对。

Bioorg Med Chem Lett. 2008 Mar 15;18(6):2073-7. doi: 10.1016/j.bmcl.2008.01.096. Epub 2008 Jan 30.

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Synthesis of DNA-interactive pyrrolo[2,1-c][1,4]benzodiazepines (PBDs).

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