School of Integrative Plant Science, Cornell University, Ithaca, NY 14850 USA.
Department of Molecular, Cellular and Biomedical Sciences, University of New Hampshire, Durham NH 03824, USA.
Trends Microbiol. 2017 Aug;25(8):624-636. doi: 10.1016/j.tim.2017.02.006. Epub 2017 Mar 7.
Historical changes in population size, such as those caused by demographic range expansions, can produce nonadaptive changes in genomic diversity through mechanisms such as gene surfing. We propose that demographic range expansion of a microbial population capable of horizontal gene exchange can result in genome surfing, a mechanism that can cause widespread increase in the pan-genome frequency of genes acquired by horizontal gene exchange. We explain that patterns of genetic diversity within Streptomyces are consistent with genome surfing, and we describe several predictions for testing this hypothesis both in Streptomyces and in other microorganisms.
历史上的人口规模变化，如人口分布范围的扩大，可能会通过基因冲浪等机制导致基因组多样性的非适应性变化。我们提出，能够进行水平基因交换的微生物种群的种群分布范围的扩大可能导致基因组冲浪，这一机制可能导致通过水平基因交换获得的基因的泛基因组频率广泛增加。我们解释了链霉菌内遗传多样性的模式与基因组冲浪一致，并描述了几个预测来检验这一假设，这些预测既适用于链霉菌，也适用于其他微生物。
