In vitro studies on the use of cetylpyridinium chloride as a bacterial plaque control agent.

Studies have shown that cetylpyridinium chloride (CPC) containing mouthwash may in vitro inhibit artificial bacterial plaque accumulation under certain conditions. These studies, together with the findings of clinical trials, suggest that the clinical activity of CPC in partially limiting plaque accumulation depends on its adherence to cleaned enamel surfaces rather than its penetration in performed plaque.