Lv Rui-Juan, Shao Xiao-Qiu, Cui Tao, Wang Qun
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantanxili, Dongcheng District, Beijing, 100050, PR China; China National Clinical Research Center for Neurological Diseases, Beijing, PR China, 6 Tiantanxili, Dongcheng District, Beijing, 100050, PR China.
Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, 6 Tiantanxili, Dongcheng District, Beijing, 100050, PR China; China National Clinical Research Center for Neurological Diseases, Beijing, PR China, 6 Tiantanxili, Dongcheng District, Beijing, 100050, PR China.
Epilepsy Res. 2017 May;132:21-28. doi: 10.1016/j.eplepsyres.2017.02.010. Epub 2017 Feb 28.
The association between the MDR1 gene C3435T polymorphism and childhood intractable epilepsy remains controversial. In this study, we performed a meta-analysis to clarify this issue. We searched the PubMed, Medline, Embase and CNKI databases for studies published through October 2016 that evaluated the association between the MDR1 C3435T polymorphism and childhood refractory epilepsy. Eleven studies involving 863 cases in the group with drug-resistant epilepsy and 915 cases in the group with drug-responsive epilepsy were included in this systematic review and meta-analysis. The analysis showed that there was not a significant association of the MDR1 C3435T polymorphism overall with risk of drug-resistance. But the allelic association of MDR1 C3435T and the association of the MDR1 3435 CC genotype with risk of drug-resistance were significant among European population and a '>2010' group based on publication year subgroup analysis. The relationship between the MDR1 C3435T polymorphism and childhood refractory epilepsy needs further validation.
多药耐药基因1（MDR1）C3435T多态性与儿童难治性癫痫之间的关联仍存在争议。在本研究中，我们进行了一项荟萃分析以阐明这一问题。我们检索了PubMed、Medline、Embase和中国知网数据库，查找截至2016年10月发表的评估MDR1 C3435T多态性与儿童难治性癫痫之间关联的研究。本系统评价和荟萃分析纳入了11项研究，其中耐药癫痫组863例，药物反应性癫痫组915例。分析表明，总体而言MDR1 C3435T多态性与耐药风险无显著关联。但基于发表年份亚组分析，在欧洲人群和“>2010”组中，MDR1 C3435T的等位基因关联以及MDR1 3435 CC基因型与耐药风险的关联具有显著性。MDR1 C3435T多态性与儿童难治性癫痫之间的关系需要进一步验证。
