Hobson Charles, Ruchi Rupam, Bihorac Azra
Department of Health Services Research, Management, and Policy, 1225 Center Drive, HPNP 4151 University of Florida Gainesville, FL 32611, USA.
Department of Medicine, University of Florida, PO Box 100254, Gainesville, FL 32610-0254, USA.
Crit Care Clin. 2017 Apr;33(2):379-396. doi: 10.1016/j.ccc.2016.12.008.
Acute kidney injury (AKI) is a common complication in surgical patients and is associated with increases in mortality, an increased risk for chronic kidney disease and hemodialysis after discharge, and increased cost. Better understanding of the risk factors that contribute to perioperative AKI has led to improved AKI prediction and will eventually lead to improved prevention of AKI, mitigation of injury when AKI occurs, and enhanced recovery in patients who sustain AKI. The development of advanced clinical prediction scores for AKI, new imaging techniques, and novel biomarkers for early detection of AKI provides new tools toward these ends.
急性肾损伤(AKI)是外科手术患者常见的并发症,与死亡率增加、出院后患慢性肾病和进行血液透析的风险增加以及成本上升相关。对围手术期AKI相关危险因素的更深入了解已改善了AKI的预测,并最终将改善AKI的预防、在AKI发生时减轻损伤以及促进AKI患者的康复。用于AKI的先进临床预测评分、新成像技术以及用于早期检测AKI的新型生物标志物的开发为实现这些目标提供了新工具。