幼儿晨间唾液皮质醇：参考值及年龄、性别和急性细支气管炎的影响
Morning Salivary Cortisol in Young Children: Reference Values and the Effects of Age, Sex, and Acute Bronchiolitis.
作者信息
Rolfsjord Leif Bjarte, Bakkeheim Egil, Berents Teresa Løvold, Alm Johan, Skjerven Håvard Ove, Carlsen Kai-Håkon, Mowinckel Petter, Sjöbeck Ann-Christine, Carlsen Karin Cecilie Lødrup
机构信息
Department of Pediatrics, Innlandet Hospital Trust, Elverum, Norway; Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Norway; Faculty of Medicine, Institute of Clinical Medicine, University of Oslo.
Division of Pediatric and Adolescent Medicine, Oslo University Hospital, Norway.
出版信息
J Pediatr. 2017 May;184:193-198.e3. doi: 10.1016/j.jpeds.2017.01.064. Epub 2017 Mar 8.
OBJECTIVE
To identify morning salivary cortisol reference values in infancy and at 2 years of age and to investigate the influence of age, sex and acute bronchiolitis.
STUDY DESIGN
In this South-East Norwegian cohort study, 308 children hospitalized with moderate to severe acute bronchiolitis in infancy in 2010-2011 were compared with 223 healthy controls included in 2012 by measuring morning salivary cortisol levels at inclusion and at 2 years of age. Samples were collected shortly after awakening after 6 am. The influences of age, sex, and acute bronchiolitis were assessed by regression analysis.
RESULTS
In infancy, cortisol values were higher in acute bronchiolitis, with an age- and sex-adjusted weighted mean group difference of 13.9 nmol/L (95% CI 8.1-19.7; P < .0001). The median level in reference group was 23.7 nmol/L (95% CI 9.7-119.6). At 2 years of age, sex but not inclusion groups differed, with significantly higher values in girls. The weighted mean of all boys' cortisol levels was 32.4 nmol/L, (95% CI 30.5-34.3), and all girls' levels were 36.9 nmol/L (95% CI 34.7-39.2; P < .003).
CONCLUSIONS
Salivary cortisol levels were higher at 2 years of age than in infancy in the reference group, were higher in girls than in boys at 2 years of age, and were higher in infants at the time of acute bronchiolitis than in healthy infants.
TRIAL REGISTRATION
ClinicalTrials.gov: NCT00817466.
目的
确定婴儿期和2岁时的晨间唾液皮质醇参考值，并研究年龄、性别和急性细支气管炎的影响。
研究设计
在这项挪威东南部队列研究中，通过测量入组时和2岁时的晨间唾液皮质醇水平，将2010 - 2011年婴儿期因中度至重度急性细支气管炎住院的308名儿童与2012年纳入的223名健康对照进行比较。样本在早上6点后醒来不久采集。通过回归分析评估年龄、性别和急性细支气管炎的影响。
结果
在婴儿期，急性细支气管炎患儿的皮质醇值较高，年龄和性别调整后的加权平均组间差异为13.9 nmol/L（95%可信区间8.1 - 19.7；P <.0001）。参考组的中位数水平为23.7 nmol/L（95%可信区间9.7 - 119.6）。在2岁时，不同的是性别而非入组情况，女孩的值显著更高。所有男孩皮质醇水平的加权平均值为32.4 nmol/L（95%可信区间30.5 - 34.3），所有女孩的水平为36.9 nmol/L（95%可信区间34.7 - 39.2；P <.003）。
结论
参考组中，2岁时的唾液皮质醇水平高于婴儿期，2岁时女孩高于男孩，急性细支气管炎婴儿期高于健康婴儿。
试验注册
ClinicalTrials.gov：NCT00817466。
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