Castillo Eliana, Murphy Kellie, van Schalkwyk Julie
Calgary, AB.
Toronto, ON.
J Obstet Gynaecol Can. 2017 Mar;39(3):181-190. doi: 10.1016/j.jogc.2016.11.001. Epub 2017 Mar 8.
To review the epidemiology, natural history, evaluation, and treatment of hepatitis B virus (HBV) infection during pregnancy. This will aid obstetric care providers in counseling their patients regarding perinatal risks and management options available to pregnant women with hepatitis B.
Outcomes evaluated include thresholds for HBV anti-viral treatment for prevention of perinatal transmission and for invasive procedures during pregnancy for women with hepatitis B infection.
Medline, EMBASE, and CINAHL were searched for articles in English on subjects related to HBV infection, pregnancy, and perinatal transmission from 1966 to March 2016. Results were restricted to systematic reviews, randomized controlled trials/controlled clinical trials, and observational studies. Other (unpublished) literature was identified through searching the websites of health technology assessment and health technology assessment-related agencies, clinical practice guideline collections, clinical trial registries, and national and international medical speciality societies.
The quality of the evidence is rated using the criteria described in the Report of the Canadian Task Force on Preventive Health Care (Table 1). Recommendations for practice are ranked according to the method described in this Report.
The guideline will be reviewed 5 years after publication to decide if an update is required. However, if important new evidence is published prior to the 5-year cycle, the review process may be accelerated for a more rapid update of some recommendations.
This guideline was developed with resources funded by the Society of Obstetricians and Gynaecologists of Canada.
综述孕期乙型肝炎病毒（HBV）感染的流行病学、自然史、评估及治疗。这将有助于产科医护人员就围产期风险以及为患乙型肝炎的孕妇提供的管理方案向患者提供咨询。
评估的结果包括预防围产期传播及对感染乙型肝炎的孕妇在孕期进行侵入性操作时HBV抗病毒治疗的阈值。
检索了1966年至2016年3月期间Medline、EMBASE和CINAHL数据库中与HBV感染、妊娠及围产期传播相关主题的英文文章。结果仅限于系统评价、随机对照试验/对照临床试验及观察性研究。通过检索卫生技术评估及与卫生技术评估相关机构的网站、临床实践指南汇编、临床试验注册库以及国家和国际医学专业学会，确定了其他（未发表的）文献。
使用加拿大预防保健工作组报告中所述的标准对证据质量进行评级（表1）。根据本报告所述方法对实践建议进行排序。
本指南将在发布5年后进行审查，以决定是否需要更新。然而，如果在5年周期之前发表了重要的新证据，审查过程可能会加快，以便更快地更新一些建议。
本指南是利用加拿大妇产科学会资助的资源制定的。
