Kennedy Grace A, Forman Sara F, Woods Elizabeth R, Hergenroeder Albert C, Mammel Kathleen A, Fisher Martin M, Ornstein Rollyn M, Callahan S Todd, Golden Neville H, Kapphahn Cynthia J, Garber Andrea K, Rome Ellen S, Richmond Tracy K
Division of Adolescent/Young Adult Medicine, Boston Children's Hospital, Boston, Massachusetts; Department of Psychology, Florida State University, Tallahassee, Florida.
Division of Adolescent/Young Adult Medicine, Boston Children's Hospital, Boston, Massachusetts.
J Adolesc Health. 2017 Jun;60(6):674-679. doi: 10.1016/j.jadohealth.2017.01.001. Epub 2017 Mar 8.
Previous research has indicated that patients with anorexia nervosa (AN) or atypical AN with premorbid history of overweight/obesity have greater weight loss and longer illness duration than patients with no such history. However, little is known about the association of premorbid overweight/obesity and receiving inpatient medical care during treatment for an eating disorder.
Using logistic regression, we sought to determine if history of overweight/obesity was associated with receiving inpatient medical care in a sample of 522 patients (mean age 15.5 years, 88% female) with AN/atypical AN.
Binary results demonstrated greater percent weight loss (27.4% vs. 16.2%) and higher percent median body mass index (%mBMI, 99.8% vs. 85.2%) at presentation in those with a history of overweight/obesity (p < .001) but no difference in duration of illness (p = .09). In models adjusted for demographics and percent weight loss, history of overweight/obesity was associated with lower odds of receiving inpatient medical care (odds ratio .60 [95% confidence interval: .45-.80]) at 1-year follow-up. However, these associations were no longer significant after adjusting for %mBMI. Mediation results suggest that %mBMI fully mediates the relationship between history of overweight/obesity and inpatient medical care, in that those with a history of overweight/obesity are less likely to receive care due to presenting at a higher weight.
Our findings suggest that, despite greater degree of weight loss and no difference in duration of illness, participants with a history of overweight/obesity are less likely to receive inpatient medical care.
先前的研究表明,患有神经性厌食症(AN)或非典型AN且病前有超重/肥胖病史的患者,比没有此类病史的患者体重减轻更多,病程更长。然而,对于病前超重/肥胖与饮食失调治疗期间接受住院医疗护理之间的关联,我们知之甚少。
我们采用逻辑回归分析,试图确定在522例患有AN/非典型AN的患者(平均年龄15.5岁,88%为女性)样本中,超重/肥胖病史是否与接受住院医疗护理有关。
二元分析结果显示,有超重/肥胖病史的患者在就诊时体重减轻百分比更高(27.4%对16.2%),中位体重指数百分比(%mBMI,99.8%对85.2%)更高(p <.001),但病程无差异(p = 0.09)。在对人口统计学和体重减轻百分比进行调整的模型中,超重/肥胖病史与1年随访时接受住院医疗护理的较低几率相关(比值比0.60 [95%置信区间:0.45 - 0.80])。然而,在对%mBMI进行调整后,这些关联不再显著。中介分析结果表明,%mBMI完全介导了超重/肥胖病史与住院医疗护理之间的关系,即有超重/肥胖病史的患者因就诊时体重较高而接受护理的可能性较小。
我们的研究结果表明,尽管体重减轻程度更大且病程无差异,但有超重/肥胖病史的参与者接受住院医疗护理的可能性较小。