CNRS, UMR 7355, Orleans, France; University of Orleans, INEM, Experimental and Molecular Immunology and Neurogenetics, Orleans, France.
CNRS, UMR 7355, Orleans, France; University of Orleans, INEM, Experimental and Molecular Immunology and Neurogenetics, Orleans, France.
Trends Microbiol. 2017 Apr;25(4):245-246. doi: 10.1016/j.tim.2017.02.009. Epub 2017 Mar 8.
In vivo animal models have intrinsic limitations for studying relationships between tuberculosis and its host and there is a need for alternative, in vitro cellular models. A microsphere-based 3D in vitro culture system of Mycobacterium tuberculosis-infected human blood mononuclear cells was reported to address specific aspects of host-pathogen interactions.
体内动物模型在研究结核分枝杆菌与其宿主之间的关系方面存在固有局限性，因此需要替代的体外细胞模型。据报道，一种基于微球的结核分枝杆菌感染人血单核细胞的 3D 体外培养系统可用于解决宿主-病原体相互作用的特定方面。
