认知功能正常且无淀粉样病变的老年人神经心理学特征的性别差异。
Gender differences of neuropsychological profiles in cognitively normal older people without amyloid pathology.
作者信息
Zhang Jie, Zhou Wenjun, Wang Lijun, Zhang Xiangyang
机构信息
Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China.
Department of Respiratory Medicine, Zhongshan Hospital, Fudan University, Shanghai, China.
出版信息
Compr Psychiatry. 2017 May;75:22-26. doi: 10.1016/j.comppsych.2017.02.008. Epub 2017 Mar 1.
Abstract
OBJECTIVE
To investigate the impact of sex on cognition among cognitively normal older people without amyloid pathology.
METHODS
The study sample consisted of 83 males (mean age 74years, ranging from 65 to 88years) and 111 females (mean age 72years, ranging from 65 to 89years) who were cognitively normal without amyloid pathology confirmed by Pittsburgh compound B PET scan. We examined the sex discrepancies in cognition using a comprehensive neuropsychological battery.
RESULTS
Our data showed significantly greater advantage for women than men on the tasks of verbal memory and category fluency while better performance of naming in men than women when age, education and depressive symptoms were considered.
CONCLUSION
These findings highlight the importance of considering sex differences in the interpretation of cognitive data which contribute to clinical diagnosis of neurodegenerative disorders, such as Alzheimer's disease.
摘要
目的
研究性别对无淀粉样蛋白病变的认知正常老年人认知能力的影响。
方法
研究样本包括83名男性（平均年龄74岁，年龄范围65至88岁）和111名女性（平均年龄72岁，年龄范围65至89岁），这些人认知正常，且经匹兹堡化合物B正电子发射断层扫描证实无淀粉样蛋白病变。我们使用一套全面的神经心理学测试组来检查认知方面的性别差异。
结果
我们的数据显示，在考虑年龄、教育程度和抑郁症状的情况下，女性在言语记忆和类别流畅性任务上比男性具有显著更大的优势，而男性在命名方面的表现优于女性。
结论
这些发现凸显了在解释认知数据时考虑性别差异的重要性，这有助于神经退行性疾病（如阿尔茨海默病）的临床诊断。
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