孟加拉国健康超重人群中心血管和代谢疾病的生物标志物
Biomarkers of cardiovascular and metabolic diseases in otherwise healthy overweight subjects in Bangladesh.
作者信息
Chhezom Kuenzang, Arslan M Iqbal, Hoque Md Mozammel, Biswas Subrata Kumar
机构信息
Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka, Bangladesh.
Department of Biochemistry and Molecular Biology, Bangabandhu Sheikh Mujib Medical University (BSMMU), Shahbag, Dhaka, Bangladesh.
出版信息
Diabetes Metab Syndr. 2017 Nov;11 Suppl 1:S381-S384. doi: 10.1016/j.dsx.2017.03.021. Epub 2017 Mar 6.
Biomarkers of cardiovascular and metabolic diseases were assessed in Bangladeshi overweight subjects categorized by Asian BMI criteria. After screening 300 people, 90 apparently healthy subjects were enrolled and grouped into normal weight, overweight and obese. Compared to normal weight, the overweight and obese groups showed significant elevation of serum triglyceride, insulin, homocysteine, insulin resistance/sensitivity, and atherogenic index of plasma. Cardiometabolic biomarkers did not differ between overweight and obese groups. Some biomarkers showed correlation with BMI in overweight but not in obese group. It was concluded that cardiometabolic biomarkers are elevated in Bangladeshi overweight subjects categorized by Asian BMI criteria.
根据亚洲BMI标准对孟加拉国超重受试者的心血管和代谢疾病生物标志物进行了评估。在筛查了300人后，90名明显健康的受试者被纳入并分为正常体重、超重和肥胖组。与正常体重组相比，超重和肥胖组的血清甘油三酯、胰岛素、同型半胱氨酸、胰岛素抵抗/敏感性以及血浆致动脉粥样硬化指数显著升高。超重和肥胖组之间的心脏代谢生物标志物没有差异。一些生物标志物在超重组中与BMI相关，但在肥胖组中不相关。得出的结论是，根据亚洲BMI标准分类的孟加拉国超重受试者的心脏代谢生物标志物升高。
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