Hosseini Seyed Ahmad, Aghamohammadi Vahideh, Ashtary-Larky Damoon, Alipour Meysam, Ghanavati Matin, Lamuchi-Deli Nasrin
Ahvaz Jundishapur University of Medical Sciences, Hyperlipidemia Research Center, Ahvaz, Iran.
Ahvaz Jundishapur University of Medical Sciences, Nutrition and Metabolic Diseases Research Center, Ahvaz, Iran.
J Vasc Bras. 2020 Sep 14;19:e20190106. doi: 10.1590/1677-5449.190106. eCollection 2020.
The association between the Metabolically Healthy Obese (MHO) phenotype in the absence of metabolic syndrome and subsequent cardiovascular disease remains unclear.
We examined the association between MHO and CVD risk in young Iranian women.
We studied 183 women aged 20-35 years from a population of 308 candidates. We classified participants into 4 phenotypes. We measured body composition, blood pressure, and biochemical factors in all participants.
The Metabolically Healthy Normal Weight (MHNW) and Normal Weight Obese (NWO) phenotypes had no statistical differences in any biochemistry variables. FBS, TG, LDL/HDL, Cholesterol/HDL, hs-CRP, and atherogenic index of plasma (AIP) were all higher in Metabolically Unhealthy Obese (MUO) than MHO individuals, whereas HDL was higher in MHO than in MUO individuals. LDL/HDL and hs-CRP were higher in MHO participants than MHNW participants, whereas HDL-c was higher in MHNW than MHO.
Results of the present study demonstrate that young women displaying the MHO phenotype have a favorable metabolic profile as shown by lower FBS, TG, LDL-c/HDL, Cho/HDL, hs-CRP, and AIP and higher HDL levels than the MUO phenotype. However, MHO individuals were still at greater risk of CVD incidence (lower HDL and higher hs-CRP levels) than MHNW individuals.
代谢健康的肥胖（MHO）表型在无代谢综合征情况下与后续心血管疾病之间的关联仍不明确。
我们研究了年轻伊朗女性中MHO与心血管疾病风险之间的关联。
我们从308名候选人群中研究了183名年龄在20 - 35岁的女性。我们将参与者分为4种表型。我们测量了所有参与者的身体成分、血压和生化因素。
代谢健康的正常体重（MHNW）和正常体重肥胖（NWO）表型在任何生化变量上均无统计学差异。代谢不健康的肥胖（MUO）个体的空腹血糖（FBS）、甘油三酯（TG）、低密度脂蛋白/高密度脂蛋白（LDL/HDL）、胆固醇/高密度脂蛋白（Cholesterol/HDL）、高敏C反应蛋白（hs-CRP）和血浆致动脉粥样硬化指数（AIP）均高于MHO个体，而MHO个体的高密度脂蛋白（HDL）高于MUO个体。MHO参与者的LDL/HDL和hs-CRP高于MHNW参与者，而MHNW的高密度脂蛋白胆固醇（HDL-c）高于MHO。
本研究结果表明，表现出MHO表型的年轻女性具有良好的代谢特征，表现为FBS、TG、低密度脂蛋白胆固醇/高密度脂蛋白（LDL-c/HDL）、胆固醇/高密度脂蛋白（Cho/HDL）、hs-CRP和AIP较低，且HDL水平高于MUO表型。然而，MHO个体发生心血管疾病的风险仍高于MHNW个体（HDL较低且hs-CRP较高）。
