Yu Miao, Chen Liangkai, Peng Zhao, Nüssler Andreas K, Wu Qinghua, Liu Liegang, Yang Wei
Department of Nutrition and Food Hygiene, Hubei Key Laboratory of Food Nutrition and Safety, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, 430030 Wuhan, China; Department of Nutrition and Food Hygiene, MOE Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, Hangkong Road 13, 430030 Wuhan, China.
Department of Traumatology, BG Trauma Center, University of Tübingen, Schnarrenbergstr. 95, 72076 Tübingen, Germany.
Toxicol In Vitro. 2017 Jun;41:150-158. doi: 10.1016/j.tiv.2017.02.011. Epub 2017 Mar 7.
Deoxynivalenol (DON) is a toxic fungal secondary metabolite produced by molds of the Fusarium genus, and it is known to cause a spectrum of diseases both in humans and animals, such as emesis, diarrhea, anorexia, immunotoxicity, hematological disorders, impairment of maternal reproduction, and fetal development. The recently revealed teratogenic potential of DON has received much attention. In various animal models, it has been shown that DON led to skeletal deformities of the fetus. However, the underlying mechanisms are not yet fully understood, and toxicological data are also scarce. Several animal research studies highlight the potential link between morphological abnormalities and changes of autophagy in the reproductive system. Because autophagy is involved in fetal development, maintenance of placental function, and bone remodeling, this mechanism has become a high priority for future research. The general aim of the present review is to deliver a comprehensive overview of the current state of knowledge of DON-induced reproductive toxicity in different animal models and to provide some prospective ideas for further research. The focus of the current review is to summarize toxic and negative effects of DON exposure on the reproductive system and the potential underlying molecular mechanisms in various animal models.
脱氧雪腐镰刀菌烯醇（DON）是镰刀菌属霉菌产生的一种有毒真菌次生代谢产物，已知它会在人类和动物中引发一系列疾病，如呕吐、腹泻、厌食、免疫毒性、血液系统紊乱、母体生殖功能受损以及胎儿发育不良。最近发现的DON的致畸潜力受到了广泛关注。在各种动物模型中，已表明DON会导致胎儿骨骼畸形。然而，其潜在机制尚未完全了解，毒理学数据也很匮乏。多项动物研究强调了生殖系统形态异常与自噬变化之间的潜在联系。由于自噬参与胎儿发育、胎盘功能维持和骨骼重塑，这一机制已成为未来研究的重中之重。本综述的总体目的是全面概述不同动物模型中DON诱导的生殖毒性的现有知识状态，并为进一步研究提供一些前瞻性思路。当前综述的重点是总结DON暴露对各种动物模型生殖系统的毒性和负面影响以及潜在的分子机制。
