Giudici Kelly Virecoulon, Kindler Joseph M, Martin Berdine R, Laing Emma M, McCabe George P, McCabe Linda D, Hausman Dorothy B, Martini Lígia Araújo, Lewis Richard D, Weaver Connie M, Peacock Munro, Hill Gallant Kathleen M
Department of Nutrition, School of Public Health, University of São Paulo, Avenida Doutor Arnaldo 715, São Paulo, CEP 01246-904 Brazil.
Department of Foods and Nutrition, University of Georgia, 305 Sanford Dr, Athens, GA 30602 USA.
Nutr Metab (Lond). 2017 Mar 7;14:25. doi: 10.1186/s12986-017-0171-9. eCollection 2017.
This study aimed to investigate the relationships among osteocalcin, leptin and metabolic health outcomes in children ages 9-13 years.
This was a cross-sectional analysis of baseline data from 161 boys and 157 girls (ages 9-13 years) who previously participated in a double-blinded randomized placebo controlled trial of vitamin D supplementation. Relationships among fasting serum total osteocalcin (tOC), undercarboxylated osteocalcin (ucOC), leptin, and metabolic health outcomes were analyzed.
Approximately 52% of study participants were obese based on percent body fat cutoffs (>25% for boys and >32% for girls) and about 5% had fasting serum glucose within the prediabetic range (i.e. 100 to 125 mg/dL). Serum tOC was not correlated with leptin, glucose, insulin, HOMA-IR, or HOMA-β after adjusting for percent body fat. However, serum ucOC negatively correlated with leptin (partial r = -0.16; = 0.04) and glucose (partial r = -0.16; = 0.04) after adjustment for percent body fat. Leptin was a positive predictor of insulin, glucose, HOMA-IR, and HOMA-β after adjusting for age, sex and percent body fat (all < 0.001).
These data depict an inverse relationship between leptin and various metabolic health outcomes in children. However, the notion that tOC or ucOC link fat with energy metabolism in healthy children was not supported.
NCT00931580.
本研究旨在调查9至13岁儿童骨钙素、瘦素与代谢健康结果之间的关系。
这是一项对161名男孩和157名女孩（9至13岁）的基线数据进行的横断面分析，这些儿童此前参与了一项维生素D补充剂的双盲随机安慰剂对照试验。分析了空腹血清总骨钙素（tOC）、未羧化骨钙素（ucOC）、瘦素与代谢健康结果之间的关系。
根据体脂百分比临界值（男孩>25%，女孩>32%），约52%的研究参与者肥胖，约5%的人空腹血清葡萄糖处于糖尿病前期范围（即100至125mg/dL）。在调整体脂百分比后，血清tOC与瘦素、葡萄糖、胰岛素、HOMA-IR或HOMA-β均无相关性。然而，在调整体脂百分比后，血清ucOC与瘦素（偏相关系数r = -0.16；P = 0.04）和葡萄糖（偏相关系数r = -0.16；P = 0.04）呈负相关。在调整年龄、性别和体脂百分比后，瘦素是胰岛素、葡萄糖、HOMA-IR和HOMA-β的正向预测因子（所有P < 0.001）。
这些数据表明儿童瘦素与各种代谢健康结果之间存在负相关关系。然而，在健康儿童中，tOC或ucOC将脂肪与能量代谢联系起来的观点未得到支持。
NCT00931580。
