Kleniewska Paulina, Pawliczak Rafał
Department of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, 7/9 Zeligowskiego St, 90-752 Lodz, Poland.
Oxid Med Cell Longev. 2017;2017:9315375. doi: 10.1155/2017/9315375. Epub 2017 Feb 13.
The aim of the present study was to assess synbiotic ( + inulin) influence on oxidative stress parameters such as concentrations of malondialdehyde (MDA), hydrogen peroxide (HO), glutathione, and free sulfhydryl groups content. Experiments were carried out on healthy volunteers ( = 32). The subjects were divided into women group ( = 16) and men group ( = 16) and randomly assigned to synbiotic and control groups. Blood samples were collected before synbiotic supplementation and after 7 wks, at the end of the study. The administration of synbiotic resulted in a significant decrease in MDA ( < 0.01), HO ( < 0.01), and GSSG concentrations ( < 0.05) as compared with the control groups and significant increase in the concentrations of GSHt ( < 0.001), GSH ( < 0.01), and -SH group content ( < 0.05) versus control. Synbiotics containing plus inulin may have positive influence on selected oxidative stress markers.
本研究的目的是评估合生元（+菊粉）对氧化应激参数的影响，如丙二醛（MDA）、过氧化氢（HO）、谷胱甘肽的浓度以及游离巯基含量。对32名健康志愿者进行了实验。受试者被分为女性组（16名）和男性组（16名），并随机分配到合生元组和对照组。在研究结束时，于补充合生元前及7周后采集血样。与对照组相比，服用合生元导致MDA（P<0.01）、HO（P<0.01）和氧化型谷胱甘肽（GSSG）浓度（P<0.05）显著降低，而总谷胱甘肽（GSHt，P<0.001）、还原型谷胱甘肽（GSH，P<0.01）浓度和-SH基团含量（P<0.05）与对照组相比显著增加。含益生菌加菊粉的合生元可能对选定的氧化应激标志物有积极影响。
